This 3D reconstructed image shows a mouse neuromuscular junction (NMJ), which is a synapse that enables muscle contraction and movement. Axon terminals were stained with anti-synaptophysin and neurofilament antibodies (green). Acetylcholine receptors in the NMJ were stained with α-bungarotoxin (red). Hongyang Jing, Minyi Wu, and colleagues explored how NMJ development requires a process called neddylation. See the article by Jing, Wu et al. for more information on the genetic interaction they discovered that regulates NMJ formation. Cover image: Hongyang Jing