Table 1 Characteristics of the study population.

From: A prospective randomized study that compares three different dressings for the prevention of surgical site infections following major heart surgery

Patients

Total

Conventional

Absorbent

Vacuum

p

N = 900

N = 300

N = 300

N = 300

Pre-operative characteristics

Median age in years (IQR)

64 (57—73)

63 (54—73)

67 (59—75)

64 (56—72)

0.002

Age > 70 years (%)

296 (32.9)

94 (31.3)

118 (39.3)

84 (28)

0.010

Sex (%)

     

Male

616 (68.4)

210 (70.0)

198 (66.0)

208 (69.3)

0.528

BMI, median (IQR)

26.2 (23.7—29.4)

25.9 (23.7—30.1)

26.1 (23.5—29.1)

26.4 (23.8—29.7)

0.894

Obesity ( body mass index > 30) (%)

205 (22.8)

76 (25.3)

60 (20.0)

69 (23.0)

0.295

Underlying conditions (%)

     

High Blood Pressure

433 (48.1)

145 (48.3)

139 (46.3)

149 (49.7)

0.713

Myocardial infarction

137 (15.2)

46 (15.3)

47 (15.7)

44 (14.7)

0.942

Congestive heart failure

198 (22)

71 (23.7)

64 (21.3)

63 (21)

0.691

Central nervous system disease

103 (11.4)

33 (11.0)

36 (12.0)

34 (11.3)

0.926

Chronic obstructive pulmonary disease

124 (13.8)

35 (11.7)

41 (13.7)

48 (16)

0.305

Renal dysfunction

65 (7.2)

12 (4.0)

29 (9.7)

24 (8)

0.022

Diabetes mellitus

239 (26.6)

63 (21.0)

96 (32.0)

80 (26.7)

0.010

Peptic ulcer disease

66 (7.3)

22 (7.3)

24 (8.0)

20 (6.7)

0.822

Peripheral vascular disease

69 (7.7)

16 (5.3)

24 (8.0)

29 (9.7)

0.132

Tumor

89 (9.9)

22 (7.3)

42 (14.0)

25 (8.3)

0.013

Positive nasal cultures, n = 215

215 (23.9)

67 (22.3)

73 (24.3)

75 (25.0)

0.728

MSSA

207 (96.3)

66 (98.5)

72 (98.6)

69 (92.0)

0.053

MRSA

8 (3.7)

1 (1.5)

1 (1.4)

6 (8.0)

 

Urgent surgery (%)

22 (2.4)

10 (3.3)

5 (1.7)

7 (2.3)

0.413

Prior Surgery (%)

119 (13.2)

44 (14.7)

40 (13.3)

35 (11.7)

0.554

Apache at inclusion, mean (SD)

8 (5—9)

7 (5—9)

8 (6—10)

8 (5—9)

0.047

Charlson (SD)

1 (0—2)

1 (0—2)

1 (0—3)

1 (0—2)

0.001

EuroScore, median (IQR)

6 (3.3—8)

6 (4—8)

6 (4—8)

6 (3—8)

0.257

Risk, EuroScore, median (IQR)

5 (2.5—10.6)

5.4 (2.7—10.2)

5.4 (2.5—11.4)

4.6 (2.3—9.6)

0.433

EuroScore II, median (IQR)

1.6 (0.9—3.1)

1.6 (0.9—3)

1.6 (0.9—3.3)

1.5 (1—3)

0.625

Operative characteristics

Type of surgery (%)

    

0.606

Valve replacement

443 (49.2)

151 (50.3)

145 (48.3)

147 (49.0)

 

CABG

275 (30.6)

83 (27.7)

99 (33.0)

93 (31.0)

 

Mixed (valve and CABG)

52 (5.8)

14 (4.7)

16 (5.3)

22 (7.3)

 

Aortic no valve + Aortic and valve

51 (5.7)

23 (7.7)

12 (4.0)

16 (5.3)

 

Congenital

31 (3.4)

12 (4.0)

12 (4.0)

7 (2.3)

 

Heart transplant

2 (0.2)

0 (0)

1 (0.3)

1 (0.3)

 

Others surgery

46 (5.1)

17 (5.7)

15 (5.0)

14 (4.7)

 

IMA, n (%)

301 (82.2)

87 (77.0)

105 (83.3)

109 (85.8)

0.187

Bilateral IMA, n (%)

88 (29.4)

24 (27.6)

32 (30.8)

32 (29.6)

0.889

Surgical data

     

Median CPBT (min) (IQR)

127 (90—168.5)

125 (91—171)

127 (90—160)

130 (88.5—173)

0.407

Median (IQR) aortic cross-clamp time (min)

83.5 (58—113)

81 (59—112)

81 (58—109)

89 (57—120)

0.164

Re- intervention (%)

71 (7.9)

26 (8.7)

26 (8.7)

19 (6.3)

0.473

Transfusion (%)

505 (56.1)

164 (54.7)

172 (57.3)

169 (56.3)

0.802

Packing (%)

33 (3.7)

11 (3.7)

11 (3.7)

11 (3.7)

1.000

Dehiscence (%)

21 (2.3)

6 (2.0)

9 (3.0)

6 (2.0)

0.645

Post-Operative characteristics

Median length of hospital stay in days (IQR)

16 (10—25)

15 (10—24)

16.5 (11—28.8)

15 (10—24)

0.201

Median length of ICU stay in days (IQR)

4 (3—6.8)

4 (2—6)

4 (3—7)

4 (3—7)

0.236

Median length preoperative in days (IQR)

2 (1—7)

2 (1—6)

2 (1—8)

2 (1—7)

0.555

Patients with MV > 48 h (%)

114 (12.7)

33 (11.0)

41 (13.7)

40 (13.3)

0.564

Days of MV

    

0.877

1 day

714 (79.3)

238 (79.3)

233 (77.7)

243 (81.0)

 

2–4 days

113 (12.6)

37 (12.3)

40 (13.3)

36 (12.0)

 

 >  = 5 days

73 (8.1)

25 (8.3)

27 (9.0)

21 (7.0)

 

Reintubation, n (%)

48 (5.4)

14 (4.7)

20 (6.7)

14 (4.7)

0.463

Delirium, (%)

41 (4.6)

14 (4.7)

12 (4.0)

15 (5.0)

0.836

Need for inotropic support (%)

817 (90.9)

262 (87.6)

279 (93.0)

276 (92.0)

0.052

DDDs, mean (SD)

7.3 (4—18.6)

7.5 (3—18.3)

8 (5.1—21)

6.6 (3.5—18.2)

0.377

Mortality (%)

40 (4.4)

14 (4.7)

17 (5.7)

9 (3.0)

0.277

PostSurgical Mediastinitis (%)

14 (1.6)

6 (2.0)

6 (2.0)

2 (0.7)

0.313

Superficial wound infection (%)

25 (2.8)

7 (2.3)

9 (3.0)

9 (3.0)

0.848

Other infection different wound surgical (%)

144 (16)

47 (15.7)

52 (17.3)

45 (15.0)

0.724

  1. BMI: body mass index; CABG: coronary artery by-pass grafting; CPBT, cardiopulmonary by-pass time; MV, mechanical ventilation; IMA: internal mammary artery; SD: standard deviation; IQR: interquartile range (P25 – P75); DDDs: defined antibiotic doses. MRSA:methicillin-resistant Staphylococcus aureus; MSSA: methicillin-susceptible S. aureus.