Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2025 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. [email protected]

https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-025-02739-0 Nature Biotechnology, Published online: 25 July 2025; doi:10.1038/s41587-025-02739-0Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.]]> Ivana BorovskáChundan ZhangSarah-Luisa J. DülkEdoardo MorandiMarta F. S. CardosoBillal M. BourkiaDaphne A. L. van den HombergMichael T. WolfingerWillem A. VelemaDanny Incarnato doi:10.1038/s41587-025-02739-0 Nature Biotechnology, Published online: 2025-07-25; | doi:10.1038/s41587-025-02739-0 2025-07-25 Nature Biotechnology 10.1038/s41587-025-02739-0 https://www.nature.com/articles/s41587-025-02739-0 https://www.nature.com/articles/s41587-025-02718-5 Nature Biotechnology, Published online: 25 July 2025; doi:10.1038/s41587-025-02718-5Matched ribosome profiling and RNA sequencing data quantify translation efficiency patterns across 140 human and mouse cell lines.]]> Yue LiuShilpa RaoIan HoskinsMichael GengQiuxia ZhaoJonathan ChackoVighnesh GhatpandeKangsheng QiLogan PersynJun WangDinghai ZhengYochen ZhongDayea ParkElif Sarinay CenikVikram AgarwalHakan OzadamCan Cenik doi:10.1038/s41587-025-02718-5 Nature Biotechnology, Published online: 2025-07-25; | doi:10.1038/s41587-025-02718-5 2025-07-25 Nature Biotechnology 10.1038/s41587-025-02718-5 https://www.nature.com/articles/s41587-025-02718-5 https://www.nature.com/articles/s41587-025-02725-6 Nature Biotechnology, Published online: 25 July 2025; doi:10.1038/s41587-025-02725-6A graph neural network framework enables individualized genetic risk prediction at the single-cell level.]]> Sai ZhangHantao ShuJingtian ZhouJasper Rubin-SiglerXiaoyu YangYuxi LiuJohnathan Cooper-KnockEmma MonteChenchen ZhuSharon TuHan LiMingming TongJoseph R. EckerJustin K. IchidaYin ShenJianyang ZengPhilip S. TsaoMichael P. Snyder doi:10.1038/s41587-025-02725-6 Nature Biotechnology, Published online: 2025-07-25; | doi:10.1038/s41587-025-02725-6 2025-07-25 Nature Biotechnology 10.1038/s41587-025-02725-6 https://www.nature.com/articles/s41587-025-02725-6 https://www.nature.com/articles/s41587-025-02733-6 Nature Biotechnology, Published online: 25 July 2025; doi:10.1038/s41587-025-02733-6RNA-binding motifs in eukaryotic proteins are presented in a comprehensive resource.]]> Alexander SasseDebashish RayKaitlin U. LavertyCyrus L. TamMihai AlbuHong ZhengYevgen LevdanskyOlga LyudovykTaykhoom DalalKate NieCedrik MagisCedric NotredameEugene ValkovMatthew T. WeirauchTimothy R. HughesQuaid Morris doi:10.1038/s41587-025-02733-6 Nature Biotechnology, Published online: 2025-07-25; | doi:10.1038/s41587-025-02733-6 2025-07-25 Nature Biotechnology 10.1038/s41587-025-02733-6 https://www.nature.com/articles/s41587-025-02733-6 https://www.nature.com/articles/s41587-025-02712-x Nature Biotechnology, Published online: 25 July 2025; doi:10.1038/s41587-025-02712-xA deep convolutional neural network model predicts the influence of the full-length mRNA sequence on translation efficiency.]]> Dinghai ZhengLogan PersynJun WangYue LiuFernando Ulloa-MontoyaCan CenikVikram Agarwal doi:10.1038/s41587-025-02712-x Nature Biotechnology, Published online: 2025-07-25; | doi:10.1038/s41587-025-02712-x 2025-07-25 Nature Biotechnology 10.1038/s41587-025-02712-x https://www.nature.com/articles/s41587-025-02712-x https://www.nature.com/articles/s41587-025-02752-3 Nature Biotechnology, Published online: 22 July 2025; doi:10.1038/s41587-025-02752-3For decades, and in the exceptional instance of the Institut Pasteur for over a century, non-profit organizations have augmented R&D to advance scientific understanding and develop affordable and accessible pipelines of vaccines, medicines and diagnostics. Small and medium enterprises and former biopharmaceutical industry executives make a sizeable contribution to global health goals by pursuing opportunities in this corner of the global biopharmaceutical ecosystem.]]> Barbara Nasto doi:10.1038/s41587-025-02752-3 Nature Biotechnology, Published online: 2025-07-22; | doi:10.1038/s41587-025-02752-3 2025-07-22 Nature Biotechnology 10.1038/s41587-025-02752-3 https://www.nature.com/articles/s41587-025-02752-3 https://www.nature.com/articles/s41587-025-02734-5 Nature Biotechnology, Published online: 22 July 2025; doi:10.1038/s41587-025-02734-5Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns.]]> Wen HuCareen FoordJustine HsuLi FanMichael J. CorleySamantha N. LanjewarSiwei XuNatan BelchikovYi HeAlina P. S. PangTarun N. BhatiaJulien JarrouxAnoushka JoglekarTeresa A. MilnerLishomwa C. NdhlovuJing ZhangEduardo ButelmanSteven A. SloanVirginia M. Y. LeeLi GanHagen U. Tilgner doi:10.1038/s41587-025-02734-5 Nature Biotechnology, Published online: 2025-07-22; | doi:10.1038/s41587-025-02734-5 2025-07-22 Nature Biotechnology 10.1038/s41587-025-02734-5 https://www.nature.com/articles/s41587-025-02734-5 https://www.nature.com/articles/s41587-025-02767-w Nature Biotechnology, Published online: 21 July 2025; doi:10.1038/s41587-025-02767-wAddendum: Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale]]> Fungmin Eric LiewRobert NogleTanus AbdallaBlake J. RasorChristina CanterRasmus O. JensenLan WangJonathan StrutzPayal ChiraniaSashini De TisseraAlexander P. MuellerZhenhua RuanAllan GaoLoan TranNancy L. EngleJason C. BromleyJames DaniellRobert ConradoTimothy J. TschaplinskiRichard J. GiannoneRobert L. HettichAshty S. KarimSéan D. SimpsonSteven D. BrownChing LeangMichael C. JewettMichael Köpke doi:10.1038/s41587-025-02767-w Nature Biotechnology, Published online: 2025-07-21; | doi:10.1038/s41587-025-02767-w 2025-07-21 Nature Biotechnology 10.1038/s41587-025-02767-w https://www.nature.com/articles/s41587-025-02767-w