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https://www.nature.com/uploads/product/ncomms/rss.png http://feeds.nature.com/ncomms/rss/current https://www.nature.com/articles/s41467-025-62093-2 Nature Communications, Published online: 27 July 2025; doi:10.1038/s41467-025-62093-2O-sulfation is a widespread modification of both endogenous and exogenous biomolecules, where the primary objective is to identify effective sulfuryl donors. Here the authors report manganese catalyzed late-stage O-sulfation with tetrabutylammonium p-nitrophenyl sulfate, which is compatible with complex natural products and pharmaceutical scaffolds.]]> Ye ZhengLi HuangChunlan SongJiakun Li doi:10.1038/s41467-025-62093-2 Nature Communications, Published online: 2025-07-27; | doi:10.1038/s41467-025-62093-2 2025-07-27 Nature Communications 10.1038/s41467-025-62093-2 https://www.nature.com/articles/s41467-025-62093-2 https://www.nature.com/articles/s41467-025-61760-8 Nature Communications, Published online: 27 July 2025; doi:10.1038/s41467-025-61760-8A genome wide association study of an African vector of schistosomiasis revealed two genomic regions associated with resistance to Schistosoma mansoni. These findings will inform novel control strategies to interrupt transmission to humans.]]> Tom PennanceJacob A. TennessenJohannie M. SpaanTammie J. McQuistanGeorge OgaraFredrick RawagoKennedy AndiegoBoaz MulongaMeredith OdhiamboMartin W. MutukuGerald M. MkojiEric S. LokerMaurice R. OdiereMichelle L. Steinauer doi:10.1038/s41467-025-61760-8 Nature Communications, Published online: 2025-07-27; | doi:10.1038/s41467-025-61760-8 2025-07-27 Nature Communications 10.1038/s41467-025-61760-8 https://www.nature.com/articles/s41467-025-61760-8 https://www.nature.com/articles/s41467-025-62291-y Nature Communications, Published online: 27 July 2025; doi:10.1038/s41467-025-62291-yThe electrocatalytic C-N coupling of CO and organic nitrogen provides a promising strategy for producing high-value chemicals. Here, the authors report an iodide ion coordination effect that generates Cuδ+ active sites, enabling the efficient electrosynthesis of acetamide from CO and amine.]]> Yun FanYunhui YanQizheng AnZhongcheng XiaYuping PanYuxuan LuZhonghuan ZhuRuiqi WangQinghua LiuYuqin ZouYongjun LiShuangyin Wang doi:10.1038/s41467-025-62291-y Nature Communications, Published online: 2025-07-27; | doi:10.1038/s41467-025-62291-y 2025-07-27 Nature Communications 10.1038/s41467-025-62291-y https://www.nature.com/articles/s41467-025-62291-y https://www.nature.com/articles/s41467-025-62177-z Nature Communications, Published online: 27 July 2025; doi:10.1038/s41467-025-62177-zDNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening avenues for the treatment of blood disorders.]]> Henry W. BellRuopeng FengManan ShahYu YaoJames DouglasPhillip A. DoerflerThiyagaraj MayuranathanMichael F. O’DeaYichao LiYong-Dong WangJingjing ZhangJoel P. MackayYong ChengKate G. R. QuinlanMitchell J. WeissMerlin Crossley doi:10.1038/s41467-025-62177-z Nature Communications, Published online: 2025-07-27; | doi:10.1038/s41467-025-62177-z 2025-07-27 Nature Communications 10.1038/s41467-025-62177-z https://www.nature.com/articles/s41467-025-62177-z https://www.nature.com/articles/s41467-025-62204-z Nature Communications, Published online: 26 July 2025; doi:10.1038/s41467-025-62204-zP-Stereogenic organophosphorus compounds are a class of highly important compounds due to their potentials in asymmetric catalysis, both as ligands or catalysts. Here the authors report a regio-, E-, and enantioselective phosphinylation of allenylic acetates with racemic secondary phosphine oxides under bimetallic Pd/Cu catalysis.]]> Gen LiShichao HongXuechen LiWenhao ZhaoChaobo YeYi YuHuajie JiangJie YuXue ZhangShengming MaQiankun Li doi:10.1038/s41467-025-62204-z Nature Communications, Published online: 2025-07-26; | doi:10.1038/s41467-025-62204-z 2025-07-26 Nature Communications 10.1038/s41467-025-62204-z https://www.nature.com/articles/s41467-025-62204-z https://www.nature.com/articles/s41467-025-62201-2 Nature Communications, Published online: 26 July 2025; doi:10.1038/s41467-025-62201-2Pressure overload in the heart, such as from aortic stenosis, triggers early molecular changes before visible damage occurs. Here, the authors show that combining proteomics, transcriptomics, and genetic data reveals key drivers of heart failure, highlighting potential targets for treatment.]]> Brian R. LindmanAndrew S. PerryMichelle L. LanceKaushik AmancherlaNamju KimQuanhu ShengPhillip LinRyan D. PfeifferEric Farber-EgerWilliam F. FearonSamir KapadiaDharam J. KumbhaniLinda GillamRavinder R. MallugariDeepak K. GuptaFrancis J. MillerAnna VatterottNatalie JacksonYan Ru SuKelsey TomasekTarek AbsiJane E. FreedmanMatthew NayorSaumya DasQuinn S. WellsMarc R. DweckRobert E. GersztenEric R. GamazonNathan R. TuckerRavi ShahSammy Elmariah doi:10.1038/s41467-025-62201-2 Nature Communications, Published online: 2025-07-26; | doi:10.1038/s41467-025-62201-2 2025-07-26 Nature Communications 10.1038/s41467-025-62201-2 https://www.nature.com/articles/s41467-025-62201-2 https://www.nature.com/articles/s41467-025-62105-1 Nature Communications, Published online: 26 July 2025; doi:10.1038/s41467-025-62105-1The barrier function of skin epidermis requires polarized secretion of lamellar bodies towards the body surface. Here, Rudd et al. identify Flower (FWE) as a novel regulator of lamellar body trafficking and a determinant of epidermal barrier function.]]> Justin C. RuddJos P. H. SmitsPatrick T. KuwongRachel E. JohnsonLouise M. N. MongaIvonne M. J. J. van Vlijmen-WillemsGreer L. PorterPeter O. HalloranKanika SharmaKarina N. SchmidtVikas KumarJustin G. MadsonMrinal K. SarkarEllen H. van den BogaardJames A. GrunkemeyerJohann E. GudjonssonSunny Y. WongCory L. SimpsonLaura A. Hansen doi:10.1038/s41467-025-62105-1 Nature Communications, Published online: 2025-07-26; | doi:10.1038/s41467-025-62105-1 2025-07-26 Nature Communications 10.1038/s41467-025-62105-1 https://www.nature.com/articles/s41467-025-62105-1 https://www.nature.com/articles/s41467-025-62284-x Nature Communications, Published online: 26 July 2025; doi:10.1038/s41467-025-62284-xThis study spatially maps MoS2 monolayer photoactivity, revealing static holes and mobile electrons with distinct redox zones. Bound excitons show higher efficiency, providing insights for designing advanced photocatalysts with improved performance.]]> Olivier HenrotteSeryio SarisFranz GröbmeyerChristoph G. GruberIsmail BilginAlexander HögeleNaomi J. HalasPeter NordlanderEmiliano CortésAlberto Naldoni doi:10.1038/s41467-025-62284-x Nature Communications, Published online: 2025-07-26; | doi:10.1038/s41467-025-62284-x 2025-07-26 Nature Communications 10.1038/s41467-025-62284-x https://www.nature.com/articles/s41467-025-62284-x