Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 1;146(3):739-748.
doi: 10.1002/ijc.32318. Epub 2019 Apr 22.

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

Quinn T Ostrom  1 , Kathleen M Egan  2 , L Burt Nabors  3 , Travis Gerke  2 , Reid C Thompson  4 , Jeffrey J Olson  5 , Renato LaRocca  6 , Sajeel Chowdhary  7 , Jeanette E Eckel-Passow  8 , Georgina Armstrong  1 , John K Wiencke  9 , Jonine L Bernstein  10 , Elizabeth B Claus  11   12 , Dora Il'yasova  13   14   15 , Christoffer Johansen  16 , Daniel H Lachance  17 , Rose K Lai  18 , Ryan T Merrell  19 , Sara H Olson  10 , Siegal Sadetzki  20   21 , Joellen M Schildkraut  22 , Sanjay Shete  23 , Richard S Houlston  24 , Robert B Jenkins  25 , Margaret R Wrensch  9 , Beatrice Melin  26 , Christopher I Amos  27 , Jason T Huse  28 , Jill S Barnholtz-Sloan  29 , Melissa L Bondy  1
Affiliations

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

Quinn T Ostrom et al. Int J Cancer. .

Abstract

Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. We assessed whether EA was associated with glioma in African Americans and Hispanics. Data were obtained for 832 cases and 675 controls from the Glioma International Case-Control Study and GliomaSE Case-Control Study previously estimated to have <80% EA, or self-identify as non-White. We estimated global and local ancestry using fastStructure and RFMix, respectively, using 1,000 genomes project reference populations. Within groups with ≥40% AA (AFR≥0.4 ), and ≥15% NAA (AMR≥0.15 ), genome-wide association between local EA and glioma was evaluated using logistic regression conditioned on global EA for all gliomas. We identified two regions (7q21.11, p = 6.36 × 10-4 ; 11p11.12, p = 7.0 × 10-4 ) associated with increased EA, and one associated with decreased EA (20p12.13, p = 0.0026) in AFR≥0.4 . In addition, we identified a peak at rs1620291 (p = 4.36 × 10-6 ) in 7q21.3. Among AMR≥0.15 , we found an association between increased EA in one region (12q24.21, p = 8.38 × 10-4 ), and decreased EA in two regions (8q24.21, p = 0. 0010; 20q13.33, p = 6.36 × 10-4 ). No other significant associations were identified. This analysis identified an association between glioma and two regions previously identified in EA populations (8q24.21, 20q13.33) and four novel regions (7q21.11, 11p11.12, 12q24.21 and 20p12.13). The identifications of novel association with EA suggest regions to target for future genetic association studies.

Keywords: genetic ancestry; genetic epidemiology; genome-wide association study; glioma.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic of data processing and imputation
Figure 2.
Figure 2.
Odds ratios, overall correlation, and −log10 p-values in non-European ancestry (EA) groups between estimates for Europeans (>=80% global European Ancestry) as compared to A) African-Americans (>=40% global African ancestry), and B) Hispanics (>=15% global Native American ancestry)
Figure 3.
Figure 3.
−log10 p-values for association between local European ancestry (EA) estimate and glioma in those with A) African-Americans (≥40% global African ancestry, GICC & GliomaSE), and B) Hispanics (≥15% global Native American ancestry, GICC only), and odds ratios and 95% confidence intervals by ancestry group associated with region of lowest p value as identified in C) African-Americans (≥40% global African ancestry, GICC & GliomaSE), and D) Hispanics (≥15% global Native American ancestry, GICC only)
Figure 4.
Figure 4.
A) Single SNP associations from 95Mb to 96Mb on chromosome 7 in AFR≥0.4 annotated with linkage disequilibrium in 1,000 genomes African ancestry super-population, B) Odds ratio and 95% confidence interval for rs1620291 by ancestry group, and C) alternate allele [C] frequencies for rs1620291 by 1000 genomes reference population and ancestry group
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014. Neuro Oncol 2017;19: v1–v88. - PMC - PubMed
    1. Leece R, Xu J, Ostrom QT, Chen Y, Kruchko C, Barnholtz-Sloan JS. Global incidence of malignant brain and other central nervous system tumors by histology, 2003-2007. Neuro Oncol 2017;19: 1553–64. - PMC - PubMed
    1. Ostrom QT, Cote DJ, Ascha M, Kruchko C, Barnholtz-Sloan JS. Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014. JAMA Oncol 2018: e181789. - PMC - PubMed
    1. Wrensch M, Lee M, Miike R, Newman B, Barger G, Davis R, Wiencke J, Neuhaus J. Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls. Am J Epidemiol 1997;145: 581–93. - PubMed
    1. Ostrom QT, Bauchet L, Davis F, Deltour I, Eastman C, Fisher JL, Pekmezci M, Turner M, Schwartzbaum J, Walsh KM, Wrensch MR, Barnholtz-Sloan JS. The epidemiology of glioma in adults: a “state of the science” review. Neuro Oncol 2014;16: 896–913. - PMC - PubMed

Publication types