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Case Reports
. 2003 Jun 5;343(2):144-6.
doi: 10.1016/s0304-3940(03)00356-2.

Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans

Brian L Schmidt  1 , Robert W Gear, Jon D Levine
Affiliations
Case Reports

Response of neuropathic trigeminal pain to the combination of low-dose nalbuphine plus naloxone in humans

Brian L Schmidt et al. Neurosci Lett. .

Abstract

We report on the response of medically refractory neuropathic trigeminal pain in three patients to intravenous administration of a combination of the kappa-partial agonist opioid nalbuphine and the opioid antagonist naloxone. Each of the three patients had developed a painful peripheral neuropathy as a complication of chemical or mechanical injury to the trigeminal nerve. Each patient had been tried on a number of analgesics, including mu-opioids, and had not gained relief or was not able to tolerate side effects of the medications. Pain intensity was measured for 3 h following drug administration using a 10 cm visual analog scale. All three patients reported marked decrease in pain following administration of the nalbuphine and naloxone combination. These findings suggest a novel approach to the management for neuropathic pain.

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