Enhancement of pentazocine analgesia by clonidine
- PMID: 1350340
- DOI: 10.1016/0304-3959(92)90054-F
Enhancement of pentazocine analgesia by clonidine
Abstract
Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.
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