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. 2005;25(2):85-90.
doi: 10.1159/000086288. Epub 2005 Jun 8.

The C3435T polymorphism of MDR1 and susceptibility to adult glioma

Katie L Miller  1 , Karl T Kelsey, John K Wiencke, Michelle Moghadassi, Rei Miike, Mei Liu, Margaret Wrensch
Affiliations

The C3435T polymorphism of MDR1 and susceptibility to adult glioma

Katie L Miller et al. Neuroepidemiology. 2005.

Abstract

Introduction: The multidrug resistance-1 (MDR1) gene encodes a pump that prevents potentially carcinogenic substances from crossing the blood-brain barrier. We compare adult glioma cases and controls for the C3435T polymorphism that has been associated with reduced MDR1 expression.

Methods: Adult glioma in the San Francisco Bay area and population-based controls were identified between 1991-1994 and 1997-1999. Genotyped cases (n = 458) and controls (n = 528) were compared using logistic regression controlling for age, gender and ethnicity, with later stratification by ethnicity, gender and histology.

Results: With CC as the referent, the TT genotype was nonsignificantly less frequent among cases compared to controls (OR, 0.87; 95% CI: 0.6, 1.2). After stratification, only male glioblastoma was associated with TT genotype (OR, 0.51; 95% CI: 0.3, 1.0).

Conclusions: Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men.

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