Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors
- PMID: 15993822
- DOI: 10.1016/j.jpain.2005.02.004
Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors
Abstract
Although epinephrine (EPI) has been suggested to contribute to the pain and hyperalgesia associated with inflammation and nerve injury, there have been very few in vivo electrophysiologic studies of the effects of EPI on nociceptors. We found with the single-unit recording technique that the intradermal administration of EPI resulted in excitation of a group of C fibers and a decrease in the mechanical activation threshold in a non-overlapping group. Unexpectedly, the fibers that were neither excited nor demonstrated a decrease in threshold demonstrated as a group a significant increase in response to sustained suprathreshold mechanical stimuli, an effect not observed in the other 2 groups of C fibers. This identifies a novel response of C-fiber nociceptors to an inflammatory mediator and suggests it is present in a class of C fibers previously considered unresponsive to hyperalgesic inflammatory mediators.
Perspective: Our study provides support for the suggestion that EPI, a neuroendocrine stress hormone as well as an inflammatory mediator, might contribute to pain syndromes, especially in the setting of chronic stress.
Similar articles
-
Responsiveness of C-fiber nociceptors to punctate force-controlled stimuli in isolated rat skin: lack of modulation by inflammatory mediators and flurbiprofen.Neurosci Lett. 2004 May 6;361(1-3):163-7. doi: 10.1016/j.neulet.2003.12.073. Neurosci Lett. 2004. PMID: 15135919
-
Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy.Neuroscience. 2005;132(1):193-201. doi: 10.1016/j.neuroscience.2004.12.036. Neuroscience. 2005. PMID: 15780478
-
Sensitization of rat dorsal horn neurons by NGF-induced subthreshold potentials and low-frequency activation. A study employing intracellular recordings in vivo.Brain Res. 2007 Sep 12;1169:34-43. doi: 10.1016/j.brainres.2007.06.054. Epub 2007 Jul 13. Brain Res. 2007. PMID: 17698048
-
Modulation of C-nociceptive Activities by Inputs from Myelinated Fibers.Adv Exp Med Biol. 2016;904:33-40. doi: 10.1007/978-94-017-7537-3_3. Adv Exp Med Biol. 2016. PMID: 26900061 Review.
-
Microneurography as a tool to study the function of individual C-fiber afferents in humans: responses from nociceptors, thermoreceptors, and mechanoreceptors.J Neurophysiol. 2018 Dec 1;120(6):2834-2846. doi: 10.1152/jn.00109.2018. Epub 2018 Sep 26. J Neurophysiol. 2018. PMID: 30256737 Review.
Cited by
-
Compromised trigemino-coerulean coupling in migraine sensitization can be prevented by blocking beta-receptors in the locus coeruleus.J Headache Pain. 2023 Dec 8;24(1):165. doi: 10.1186/s10194-023-01691-1. J Headache Pain. 2023. PMID: 38062355 Free PMC article.
-
Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.Pain. 2014 Nov;155(11):2390-9. doi: 10.1016/j.pain.2014.09.009. Epub 2014 Sep 16. Pain. 2014. PMID: 25218601 Free PMC article.
-
Chronic Social Stress Time-Dependently Affects Neuropathic Pain-Related Cold Allodynia and Leads to Altered Expression of Spinal Biochemical Mediators.Front Behav Neurosci. 2017 May 9;11:70. doi: 10.3389/fnbeh.2017.00070. eCollection 2017. Front Behav Neurosci. 2017. PMID: 28536509 Free PMC article.
-
Lack of endogenous modulation and reduced decay of prolonged heat pain in older adults.Pain. 2010 Jul;150(1):153-160. doi: 10.1016/j.pain.2010.04.020. Epub 2010 May 23. Pain. 2010. PMID: 20546997 Free PMC article.
-
Intestinal afferent nerve sensitivity is increased during the initial development of postoperative ileus in mice.J Gastrointest Surg. 2009 Mar;13(3):423-31. doi: 10.1007/s11605-008-0789-z. Epub 2009 Jan 7. J Gastrointest Surg. 2009. PMID: 19130152
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
