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. 2017 Jan 16:7:40363.
doi: 10.1038/srep40363.

Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study

Norimasa Kikuchi  1   2 , Takeshi Nishiyama  2 , Takayuki Sawada  1   2 , Chaochen Wang  2 , Yingsong Lin  2 , Yoshiyuki Watanabe  3 , Akiko Tamakoshi  4 , Shogo Kikuchi  2
Affiliations

Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study

Norimasa Kikuchi et al. Sci Rep. .

Abstract

Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.

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References

    1. Haggar F. A. & Boushey R. P. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors. Clin. Colon Rectal Surg. 22, 191–197 (2009). - PMC - PubMed
    1. Howlader, N., Noone, A. M., Krapcho, M., Garshell, J., Miller, D., Altekruse, S. F., Kosary, C. L., Yu, M., Ruhl, J., Tatalovich, Z., Mariotto, A., Lewis, D. R., Chen, H. S., Feuer, E. J., Cronin, K. A. (eds). Cancer Statistics Review, 1975–2012 - SEER Statistics. National Cancer Institute. Bethesda, MD.
    1. Veer, P. van’t & Kampman, E. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a global perspective. (World Cancer Research Fund/American Institute for Cancer Research, 2007).
    1. Johnson C. M. et al.. Meta-analyses of Colorectal Cancer Risk Factors. Cancer Causes Control CCC 24, 1207–1222 (2013). - PMC - PubMed
    1. Jokela M. et al.. Is personality associated with cancer incidence and mortality? An individual-participant meta-analysis of 2156 incident cancer cases among 42 843 men and women. Br. J. Cancer 110, 1820–1824 (2014). - PMC - PubMed

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