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. 2008 Mar;135(1-2):98-107.
doi: 10.1016/j.pain.2007.05.012. Epub 2007 Jun 27.

Proinflammatory cytokines mediating burn-injury pain

Gretchen J Summer  1 , Edgar Alfonso Romero-Sandoval, Oliver Bogen, Olayinka A Dina, Sachia G Khasar, Jon D Levine
Affiliations

Proinflammatory cytokines mediating burn-injury pain

Gretchen J Summer et al. Pain. 2008 Mar.

Abstract

Thermal burns induce pain at the site of injury, mechanical hyperalgesia, associated with a complex time-dependent inflammatory response. To determine the contribution of inflammatory mediators to burn injury-induced mechanical hyperalgesia, we measured dynamic changes in the levels of three potent hyperalgesic cytokines, interleukin IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNFalpha), in skin of the rat, following a partial-thickness burn injury. Only IL-6 demonstrated a sustained increase ipsilateral but not contralateral to the burn, correlating with the prolonged ipsilateral mechanical hyperalgesia. Spinal intrathecal injection of oligodeoxynucleotides antisense for gp130, a receptor subunit shared by members of the IL-6 family of cytokines, attenuated both burn- and intradermal IL-6-induced hyperalgesia, as did intradermal injection of anti-IL-6 function blocking antibodies. These studies suggest that IL-6 is an important mediator of burn-injury pain.

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