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Clinical Trial
. 1991 Oct;47(1):21-23.
doi: 10.1016/0304-3959(91)90006-J.

Lack of effect of ephedrine on opiate analgesia

Newton C Gordon  1 , Philip H Heller, Jon D Levine
Affiliations
Clinical Trial

Lack of effect of ephedrine on opiate analgesia

Newton C Gordon et al. Pain. 1991 Oct.

Abstract

Opiate-adrenomimetic interaction was investigated by studying the effect of the adrenomimetic agent, ephedrine, on the analgesia produced by intravenous placebo and that produced by the predominantly kappa opiate agonist, pentazocine, in patients with dental postoperative pain. Ephedrine did not significantly affect the analgesia of intravenous placebo or of pentazocine. These results contrast with earlier studies demonstrating enhancement of opiate analgesia by other adrenomimetics. Further clinical studies are needed to delineate the specificity of opiate-adrenomimetic interaction.

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