Brain systems mediating aversive conditioning: an event-related fMRI study
- PMID: 9620699
- DOI: 10.1016/s0896-6273(00)80476-6
Brain systems mediating aversive conditioning: an event-related fMRI study
Abstract
We have used event-related functional magnetic resonance imaging (fMRI) to characterize neural responses associated with emotional learning. Employing a classical conditioning paradigm in which faces were conditioned by pairing with an aversive tone (US), we compared responses evoked by conditioned (CS+) and nonconditioned (CS-) stimuli. Pairing 50% of the CS+ with the US enabled us to constrain our analysis to responses evoked by a CS+ not followed by a US. Differential evoked responses, related to conditioning, were found in the anterior cingulate and the anterior insula, regions with known involvement in emotional processing. Differential responses of the amygdalae were best characterized by a time by stimulus interaction indicating a rapid adaptation of CS+-specific responses in this region.
Similar articles
-
Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging.J Neurosci. 1999 Dec 15;19(24):10869-76. doi: 10.1523/JNEUROSCI.19-24-10869.1999. J Neurosci. 1999. PMID: 10594068 Free PMC article. Clinical Trial.
-
Learning pain-related fear: neural mechanisms mediating rapid differential conditioning, extinction and reinstatement processes in human visceral pain.Neurobiol Learn Mem. 2014 Dec;116:36-45. doi: 10.1016/j.nlm.2014.08.003. Epub 2014 Aug 13. Neurobiol Learn Mem. 2014. PMID: 25128878
-
Dopamine-induced changes in neural network patterns supporting aversive conditioning.Brain Res. 2010 Feb 8;1313:143-61. doi: 10.1016/j.brainres.2009.11.064. Epub 2009 Dec 2. Brain Res. 2010. PMID: 19961836 Clinical Trial.
-
Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analyses.Neuropsychologia. 2003;41(2):184-94. doi: 10.1016/s0028-3932(02)00148-3. Neuropsychologia. 2003. PMID: 12459216
-
Contributions of anterior cingulate cortex to behaviour.Brain. 1995 Feb;118 ( Pt 1):279-306. doi: 10.1093/brain/118.1.279. Brain. 1995. PMID: 7895011 Review.
Cited by
-
Shared Neural Mechanisms for the Evaluation of Intense Sensory Stimulation and Economic Reward, Dependent on Stimulation-Seeking Behavior.J Neurosci. 2016 Sep 28;36(39):10026-38. doi: 10.1523/JNEUROSCI.1048-16.2016. Epub 2016 Sep 28. J Neurosci. 2016. PMID: 27683900 Free PMC article.
-
Classical conditioning in borderline personality disorder: an fMRI study.Eur Arch Psychiatry Clin Neurosci. 2016 Jun;266(4):291-305. doi: 10.1007/s00406-015-0593-1. Epub 2015 Mar 27. Eur Arch Psychiatry Clin Neurosci. 2016. PMID: 25814470
-
Augmenting extinction learning with D-cycloserine reduces return of fear: a randomized, placebo-controlled fMRI study.Neuropsychopharmacology. 2020 Feb;45(3):499-506. doi: 10.1038/s41386-019-0552-z. Epub 2019 Oct 21. Neuropsychopharmacology. 2020. PMID: 31634897 Free PMC article. Clinical Trial.
-
Prospective investigation into the influence of various stressors on skin impedance.J Clin Monit Comput. 2008 Feb;22(1):67-74. doi: 10.1007/s10877-007-9107-7. Epub 2007 Nov 30. J Clin Monit Comput. 2008. PMID: 18049905
-
Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure.Neurobiol Stress. 2022 Oct 17;21:100497. doi: 10.1016/j.ynstr.2022.100497. eCollection 2022 Nov. Neurobiol Stress. 2022. PMID: 36532365 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
