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. 2011 Sep 1;174(5):574-81.
doi: 10.1093/aje/kwr124. Epub 2011 Jul 8.

Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking

Daniel H Lachance  1 , Ping Yang, Derek R Johnson, Paul A Decker, Thomas M Kollmeyer, Lucie S McCoy, Terri Rice, Yuanyuan Xiao, Francis Ali-Osman, Frances Wang, Shawn M Stoddard, Debra J Sprau, Matthew L Kosel, John K Wiencke, Joseph L Wiemels, Joseph S Patoka, Faith Davis, Bridget McCarthy, Amanda L Rynearson, Joel B Worra, Brooke L Fridley, Brian Patrick O'Neill, Jan C Buckner, Dora Il'yasova, Robert B Jenkins, Margaret R Wrensch
Affiliations

Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking

Daniel H Lachance et al. Am J Epidemiol. .

Abstract

Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratio(allergy-glioma) = 0.40, 95% confidence interval: 0.28, 0.58) versus those who did (odds ratio(allergy-glioma) = 0.76, 95% confidence interval: 0.59, 0.97; P(interaction) = 0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratio(allergy-glioma) = 0.44, 95% confidence interval: 0.29, 0.68) versus those who did not carry (odds ratio(allergy-glioma) = 0.68, 95% confidence interval: 0.54, 0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P = 0.14). No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.

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