Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery
- PMID: 24411993
- PMCID: PMC4331184
- DOI: 10.1016/j.jpain.2013.09.015
Associations between cytokine gene variations and severe persistent breast pain in women following breast cancer surgery
Abstract
Persistent pain following breast cancer surgery is a significant clinical problem. Although immune mechanisms may play a role in the development and maintenance of persistent pain, few studies have evaluated for associations between persistent breast pain following breast cancer surgery and variations in cytokine genes. In this study, associations between previously identified extreme persistent breast pain phenotypes (ie, no pain vs severe pain) and single nucleotide polymorphisms (SNPs) spanning 15 cytokine genes were evaluated. In unadjusted analyses, the frequency of 13 SNPs and 3 haplotypes in 7 genes differed significantly between the no pain and severe pain classes. After adjustment for preoperative breast pain and the severity of average postoperative pain, 1 SNP (ie, interleukin [IL] 1 receptor 2 rs11674595) and 1 haplotype (ie, IL10 haplotype A8) were associated with pain group membership. These findings suggest a role for cytokine gene polymorphisms in the development of persistent breast pain following breast cancer surgery.
Perspective: This study evaluated for associations between cytokine gene variations and the severity of persistent breast pain in women following breast cancer surgery. Variations in 2 cytokine genes were associated with severe breast pain. The results suggest that cytokines play a role in the development of persistent postsurgical pain.
Keywords: Cytokines; breast cancer surgery; candidate genes; persistent pain; polymorphism.
Copyright © 2014 American Pain Society. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
No conflicts of interest exist.
Figures


Similar articles
-
Variations in potassium channel genes are associated with distinct trajectories of persistent breast pain after breast cancer surgery.Pain. 2015 Mar;156(3):371-380. doi: 10.1097/01.j.pain.0000460319.87643.11. Pain. 2015. PMID: 25599232
-
Associations Between Catecholaminergic and Serotonergic Genes and Persistent Arm Pain Severity Following Breast Cancer Surgery.J Pain. 2019 Sep;20(9):1100-1111. doi: 10.1016/j.jpain.2019.03.008. Epub 2019 Mar 21. J Pain. 2019. PMID: 30904518 Free PMC article.
-
Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery.J Pain. 2018 Oct;19(10):1130-1146. doi: 10.1016/j.jpain.2018.04.007. Epub 2018 Apr 30. J Pain. 2018. PMID: 29723560
-
Treating Persistent Pain After Breast Cancer Surgery.Drugs. 2020 Jan;80(1):23-31. doi: 10.1007/s40265-019-01227-5. Drugs. 2020. PMID: 31784873 Review.
-
Prevalence and intensity of persistent post-surgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies.Br J Anaesth. 2020 Sep;125(3):346-357. doi: 10.1016/j.bja.2020.04.088. Epub 2020 Jun 28. Br J Anaesth. 2020. PMID: 32611524
Cited by
-
Genetic Polymorphisms of Cytokines Might Affect Postoperative Sufentanil Dosage for Analgesia in Patients.J Pain Res. 2020 Jun 16;13:1461-1470. doi: 10.2147/JPR.S250174. eCollection 2020. J Pain Res. 2020. PMID: 32606912 Free PMC article.
-
Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery.J Pain Res. 2015 Nov 27;8:829-44. doi: 10.2147/JPR.S90434. eCollection 2015. J Pain Res. 2015. PMID: 26664154 Free PMC article.
-
Associations between genetic and epigenetic variations in cytokine genes and mild persistent breast pain in women following breast cancer surgery.Cytokine. 2017 Nov;99:203-213. doi: 10.1016/j.cyto.2017.07.006. Epub 2017 Jul 29. Cytokine. 2017. PMID: 28764974 Free PMC article.
-
Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort study.Hum Genomics. 2019 Jun 13;13(1):28. doi: 10.1186/s40246-019-0212-8. Hum Genomics. 2019. PMID: 31196165 Free PMC article.
-
Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.J Pain. 2020 Jan-Feb;21(1-2):2-24. doi: 10.1016/j.jpain.2019.05.008. Epub 2019 May 23. J Pain. 2020. PMID: 31129315 Free PMC article.
References
-
- Abhimanyu, Mangangcha IR, Jha P, Arora K, Mukerji M, Banavaliker JN, Brahmachari V, Bose M. Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis. Infect Genet Evol. 2011;11(5):1015–1022. - PubMed
-
- Andersen KG, Kehlet H. Persistent pain after breast cancer treatment: a critical review of risk factors and strategies for prevention. J Pain. 2011;12(7):725–746. - PubMed
-
- Bhave G, Gereau RWt. Posttranslational mechanisms of peripheral sensitization. J Neurobiol. 2004;61(1):88–106. - PubMed
-
- Carpenter JS, Andrykowski MA, Sloan P, Cunningham L, Cordova MJ, Studts JL, McGrath PC, Sloan D, Kenady DE. Postmastectomy/postlumpectomy pain in breast cancer survivors. J Clin Epidemiol. 1998;51(12):1285–1292. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
- R01 CA118658/CA/NCI NIH HHS/United States
- R01 CA107091/CA/NCI NIH HHS/United States
- F31NR012604/NR/NINR NIH HHS/United States
- KL2TR000143/TR/NCATS NIH HHS/United States
- KL2RR624130/RR/NCRR NIH HHS/United States
- CA107091/CA/NCI NIH HHS/United States
- T32NR07088/NR/NINR NIH HHS/United States
- F31 NR012604/NR/NINR NIH HHS/United States
- CA118658/CA/NCI NIH HHS/United States
- K23 AT005340/AT/NCCIH NIH HHS/United States
- KL2 TR000143/TR/NCATS NIH HHS/United States
- T32 NR007088/NR/NINR NIH HHS/United States
- UL1 RR024131/RR/NCRR NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical