doi: 10.1016/0006-291x(87)90675-9.
Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide
- PMID: 3103620
- DOI: 10.1016/0006-291x(87)90675-9
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Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide
Biochem Biophys Res Commun.
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Abstract
The poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide had dramatically different effects on X-ray-induced cytogenetic damage in human lymphocytes depending on the stage of the cell cycle in which cells were irradiated. 3-Aminobenzamide (0.08-3.00 mM) potentiated the frequency of chromosomal aberrations when lymphocytes were irradiated in G1, S, or late G2. No effect was observed, however, when lymphocytes were irradiated in G0 or at the S/G2 boundary 6 h before termination of culture. These results indicate that poly(ADP-ribose) polymerase may be involved in chromosomal repair of radiation damage only during specific stages of the cell cycle.
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