Sleep fragmentation in the arthritic rat
- PMID: 3405623
- DOI: 10.1016/0304-3959(88)90186-8
Sleep fragmentation in the arthritic rat
Abstract
We examined the diurnal sleep-wake patterns in the adjuvant arthritic rat. In contrast to control rats, arthritic rats lacked a normal diurnal variation in sleep and wakefulness. Thus, arthritic rats exhibited no differences in the mean number or duration of bouts of sleep and episodes of wakefulness between light and dark hours. Arthritic rats also had a marked increase in the fragmentation of their sleep manifested by an increased number of sleep bouts and episodes of wakefulness and a decrease in the duration of episodes of deep sleep recorded both during the time of maximal sleep (08.00-11.00 h) and of maximal wakefulness (20.00-23.00 h). The possibility that the experience of chronic pain causes these marked changes in sleep patterns in the arthritic rat is discussed.
Similar articles
-
Decreased slow-wave and paradoxical sleep in a rat chronic pain model.Sleep. 1989 Apr;12(2):167-77. doi: 10.1093/sleep/12.2.167. Sleep. 1989. PMID: 2711092
-
Differential effects of acetylsalicylic acid and acetaminophen on sleep abnormalities in a rat chronic pain model.Brain Res. 1989 May 29;488(1-2):195-201. doi: 10.1016/0006-8993(89)90709-9. Brain Res. 1989. PMID: 2743114
-
Effects of an eight-hour advance of the light-dark cycle on sleep-wake rhythm in the rat.Neurosci Lett. 1992 Mar 30;137(2):161-4. doi: 10.1016/0304-3940(92)90394-m. Neurosci Lett. 1992. PMID: 1584456
-
Circadian Rhythm Sleep-Wake Disorders.Continuum (Minneap Minn). 2017 Aug;23(4, Sleep Neurology):1051-1063. doi: 10.1212/CON.0000000000000499. Continuum (Minneap Minn). 2017. PMID: 28777176 Review.
-
[Sleep and circadian rhythms].Ugeskr Laeger. 2018 Sep 3;180(36):V05180319. Ugeskr Laeger. 2018. PMID: 30348254 Review. Danish.
Cited by
-
Dynamics of Circadian Thalamocortical Flow of Information during a Peripheral Neuropathic Pain Condition.Front Integr Neurosci. 2011 Aug 23;5:43. doi: 10.3389/fnint.2011.00043. eCollection 2011. Front Integr Neurosci. 2011. PMID: 22007162 Free PMC article.
-
Neuropathic pain impairs sleep architecture, non-rapid eye movement sleep, and reticular thalamic neuronal activity.Int J Neuropsychopharmacol. 2025 May 9;28(5):pyaf017. doi: 10.1093/ijnp/pyaf017. Int J Neuropsychopharmacol. 2025. PMID: 40121517 Free PMC article.
-
Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.Pain. 2011 May;152(5):990-1000. doi: 10.1016/j.pain.2010.12.003. Epub 2011 Jan 21. Pain. 2011. PMID: 21256675 Free PMC article.
-
Characterization of alterations in spontaneous behaviors in a rat model of neuropathic pain - new outcome measures for pain evaluation?Front Behav Neurosci. 2025 Jun 6;19:1550476. doi: 10.3389/fnbeh.2025.1550476. eCollection 2025. Front Behav Neurosci. 2025. PMID: 40546246 Free PMC article.
-
Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion.Sleep. 2014 Sep 1;37(9):1513-23. doi: 10.5665/sleep.4002. Sleep. 2014. PMID: 25142572 Free PMC article.
