Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes

doi:10.1016/j.sleep.2022.04.023

. 2022 Jul:95:91-104.

doi: 10.1016/j.sleep.2022.04.023. Epub 2022 May 2.

Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes

Affiliations

¹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
³ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁴ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁵ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁶ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁷ Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].
⁸ School of Medicine, University of Arkansas, Little Rock, AK, USA. Electronic address: [email protected].
⁹ School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: [email protected].
¹⁰ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹² Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 35569331
DOI: 10.1016/j.sleep.2022.04.023

Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes

Alejandra Calvo-Schimmel et al. Sleep Med. 2022 Jul.

. 2022 Jul:95:91-104.

doi: 10.1016/j.sleep.2022.04.023. Epub 2022 May 2.

Authors

Affiliations

¹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
³ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁴ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁵ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁶ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁷ Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].
⁸ School of Medicine, University of Arkansas, Little Rock, AK, USA. Electronic address: [email protected].
⁹ School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: [email protected].
¹⁰ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹² Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 35569331
DOI: 10.1016/j.sleep.2022.04.023

Abstract

Objective: /Background - Depression and sleep disturbance are significant problems during chemotherapy. Study purposes were to identify subgroups of patients with distinct joint depression AND sleep disturbance profiles and evaluate for differences in demographic and clinical characteristics, severity of symptoms, and quality of life (QOL) outcomes among these subgroups.

Patients/methods: Oncology outpatients (n = 1331) completed measures of depression and sleep disturbance six times over two chemotherapy cycles. Latent profile analysis, that modeled the two symptoms together, was done to identify the distinct joint depression and sleep disturbance profiles.

Results: Five distinct profiles were identified (i.e., no depression or sleep disturbance (None, 21.4%); no depression and moderate sleep disturbance (32.3%); subsyndromal depression and very high sleep disturbance (20.4%); moderate depression and moderate sleep disturbance (17.7%); and high depression and very high sleep disturbance (8.2%)). Compared to the None class, the other four classes were more likely to be female; less likely to be employed; had a higher comorbidity burden; and had a lower functional status. Patients in the two very high sleep disturbance classes had problems with both sleep initiation and maintenance. These patients reported higher levels of depressive symptoms, trait and state anxiety, and fatigue as well as lower levels of energy, cognitive function, and poorer QOL.

Conclusions: Over 45% of the patients had subsyndromal to high levels of depression AND moderate or very high levels of sleep disturbance. Characteristics associated with the higher risk profiles can be used to screen patients at increased risk for both symptoms.

Keywords: Cancer; Chemotherapy; Depression; Insomnia; Latent profile analysis; Quality of life; Sleep disturbance.

PubMed Disclaimer

Cited by

Feasibility and Acceptability of Using Wireless Limited Polysomnography to Capture Sleep Before, During, and After Hospitalization for Patients With Planned Cardiothoracic Surgery.
Cordoza ML, Anderson BJ, Cevasco M, Diamond JM, Younes M, Gerardy B, Iroegbu C, Riegel B. Cordoza ML, et al. J Cardiovasc Nurs. 2025 May-Jun 01;40(3):E110-E116. doi: 10.1097/JCN.0000000000001092. Epub 2024 Mar 21. J Cardiovasc Nurs. 2025. PMID: 38509035
Comparing the sensitivity of fatigue and sleep disturbance assessment tools in women with advanced cancer undergoing chemotherapy.
Chou HL, Chen TC, Yao CT. Chou HL, et al. Asia Pac J Oncol Nurs. 2023 Oct 31;11(2):100331. doi: 10.1016/j.apjon.2023.100331. eCollection 2024 Feb. Asia Pac J Oncol Nurs. 2023. PMID: 38283667 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes

Affiliations

Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical