Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

doi:10.1016/j.sleep.2022.11.014

. 2023 Jan:101:305-315.

doi: 10.1016/j.sleep.2022.11.014. Epub 2022 Nov 21.

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

Affiliations

¹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
³ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁴ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁵ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁶ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁷ Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].
⁸ School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: [email protected].
⁹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹⁰ Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: [email protected].
¹¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 36470166
PMCID: PMC11200329
DOI: 10.1016/j.sleep.2022.11.014

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

Alejandra Calvo-Schimmel et al. Sleep Med. 2023 Jan.

. 2023 Jan:101:305-315.

doi: 10.1016/j.sleep.2022.11.014. Epub 2022 Nov 21.

Authors

Affiliations

¹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
³ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁴ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁵ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁶ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
⁷ Dana Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].
⁸ School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: [email protected].
⁹ Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹⁰ Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. Electronic address: [email protected].
¹¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].
¹² Department of Physiological Nursing, University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 36470166
PMCID: PMC11200329
DOI: 10.1016/j.sleep.2022.11.014

Abstract

Objective/background: Sleep disturbance is a common problem in patients receiving chemotherapy. Purpose was to evaluate for perturbations in immune-inflammatory pathways between oncology patients with low versus very high levels of sleep disturbance.

Patients/methods: Sleep disturbance was evaluated using the General Sleep Disturbance Scale six times over two cycles of chemotherapy. Latent profile analysis was used to identify subgroups of patients with distinct sleep disturbance profiles. Pathway impact analyses were performed in two independent samples using gene expression data obtained from RNA sequencing (n = 198) and microarray (n = 162) technologies. Fisher's combined probability test was used to identify significantly perturbed pathways between Low versus Very High sleep disturbance classes.

Results: In the RNA sequencing and microarray samples, 59.1% and 51.9% of patients were in the Very High sleep disturbance class, respectively. Thirteen perturbed pathways were related to immune-inflammatory mechanisms (i.e., endocytosis, phagosome, antigen processing and presentation, natural killer cell mediated cytotoxicity, cytokine-cytokine receptor interaction, apoptosis, neutrophil extracellular trap formation, nucleotide-binding and oligomerization domain-like receptor signaling, Th17 cell differentiation, intestinal immune network for immunoglobulin A production, T-cell receptor signaling, complement and coagulation cascades, and tumor necrosis factor signaling).

Conclusions: First study to identify perturbations in immune-inflammatory pathways associated with very high levels of sleep disturbance in oncology outpatients. Findings suggest that complex immune-inflammatory interactions underlie sleep disturbance.

Keywords: Cancer; Chemotherapy; Immune mechanisms; Inflammation; Insomnia; Pathway impact analysis; Sleep disturbance.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors have no conflicts of interest to declare.

Cited by

The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system.
Rong M, Jia JJ, Lin MQ, He XL, Xie ZY, Wang N, Zhang ZH, Dong YJ, Xu WF, Huang JH, Li B, Jiang NH, Lv GY, Chen SH. Rong M, et al. Chin Med. 2024 Jun 12;19(1):84. doi: 10.1186/s13020-024-00939-5. Chin Med. 2024. PMID: 38867320 Free PMC article.

References

1. Tejada M, Viele C, Kober KM, Cooper BA, Paul SM, Dunn LB, et al. Identification of subgroups of chemotherapy patients with distinct sleep disturbance profiles and associated co-occurring symptoms. Sleep 2019;42. - PMC - PubMed
1. Enderlin CA, Coleman EA, Cole C, Richards KC, Hutchins LF, Sherman AC. Sleep across chemotherapy treatment: a growing concern for women older than 50 with breast cancer. Oncol Nurs Forum 2010;37. 461–A3. - PubMed
1. Hoang HTX, Molassiotis A, Chan CW, Nguyen TH, Liep Nguyen V. New-onset insomnia among cancer patients undergoing chemotherapy: prevalence, risk factors, and its correlation with other symptoms. Sleep Breath 2020;24: 241–51. - PubMed
1. Souza R, Dos Santos MR, das Chagas Valota IA, Sousa CS, Costa Calache ALS. Factors associated with sleep quality during chemotherapy: an integrative review. Nurs Open 2020;7:1274–84. - PMC - PubMed
1. Sanford SD, Wagner LI, Beaumont JL, Butt Z, Sweet JJ, Cella D. Longitudinal prospective assessment of sleep quality: before, during, and after adjuvant chemotherapy for breast cancer. Support Care Cancer 2013;21:959–67. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

[1] Tejada M, Viele C, Kober KM, Cooper BA, Paul SM, Dunn LB, et al. Identification of subgroups of chemotherapy patients with distinct sleep disturbance profiles and associated co-occurring symptoms. Sleep 2019;42. - PMC - PubMed

[2] Tejada M, Viele C, Kober KM, Cooper BA, Paul SM, Dunn LB, et al. Identification of subgroups of chemotherapy patients with distinct sleep disturbance profiles and associated co-occurring symptoms. Sleep 2019;42. - PMC - PubMed

[3] Enderlin CA, Coleman EA, Cole C, Richards KC, Hutchins LF, Sherman AC. Sleep across chemotherapy treatment: a growing concern for women older than 50 with breast cancer. Oncol Nurs Forum 2010;37. 461–A3. - PubMed

[4] Enderlin CA, Coleman EA, Cole C, Richards KC, Hutchins LF, Sherman AC. Sleep across chemotherapy treatment: a growing concern for women older than 50 with breast cancer. Oncol Nurs Forum 2010;37. 461–A3. - PubMed

[5] Hoang HTX, Molassiotis A, Chan CW, Nguyen TH, Liep Nguyen V. New-onset insomnia among cancer patients undergoing chemotherapy: prevalence, risk factors, and its correlation with other symptoms. Sleep Breath 2020;24: 241–51. - PubMed

[6] Hoang HTX, Molassiotis A, Chan CW, Nguyen TH, Liep Nguyen V. New-onset insomnia among cancer patients undergoing chemotherapy: prevalence, risk factors, and its correlation with other symptoms. Sleep Breath 2020;24: 241–51. - PubMed

[7] Souza R, Dos Santos MR, das Chagas Valota IA, Sousa CS, Costa Calache ALS. Factors associated with sleep quality during chemotherapy: an integrative review. Nurs Open 2020;7:1274–84. - PMC - PubMed

[8] Souza R, Dos Santos MR, das Chagas Valota IA, Sousa CS, Costa Calache ALS. Factors associated with sleep quality during chemotherapy: an integrative review. Nurs Open 2020;7:1274–84. - PMC - PubMed

[9] Sanford SD, Wagner LI, Beaumont JL, Butt Z, Sweet JJ, Cella D. Longitudinal prospective assessment of sleep quality: before, during, and after adjuvant chemotherapy for breast cancer. Support Care Cancer 2013;21:959–67. - PubMed

[10] Sanford SD, Wagner LI, Beaumont JL, Butt Z, Sweet JJ, Cella D. Longitudinal prospective assessment of sleep quality: before, during, and after adjuvant chemotherapy for breast cancer. Support Care Cancer 2013;21:959–67. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

Affiliations

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical