Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 18;51(3):263-274.
doi: 10.1188/24.ONF.263-274.

Self-Reported Cancer-Related Cognitive Impairment in Patients With Breast Cancer Is Associated With Potassium Channel Gene Polymorphisms

Kate R Oppegaard  1 , Marilyn J Hammer  2 , Yvette P Conley  3 , Carolyn S Harris  3 , Bruce A Cooper  1 , Steven M Paul  1 , Joosun Shin  1 , Lisa Morse  1 , Gary M Abrams  1 , Jon D Levine  1 , Christine Miaskowski  1
Affiliations

Self-Reported Cancer-Related Cognitive Impairment in Patients With Breast Cancer Is Associated With Potassium Channel Gene Polymorphisms

Kate R Oppegaard et al. Oncol Nurs Forum. .

Abstract

Objectives: To evaluate for associations of polymorphisms for potassium channel genes in patients with breast cancer who were classified as having high or low-moderate levels of cancer-related cognitive impairment (CRCI).

Sample & setting: 397 women who were scheduled to undergo surgery for breast cancer on one breast were recruited from breast care centers located in a comprehensive cancer center, two public hospitals, and four community practices.

Methods & variables: CRCI was assessed using the Attentional Function Index prior to and for six months after surgery. The attentional function classes were identified using growth mixture modeling.

Results: Differences between patients in the high versus low-moderate attentional function classes were evaluated. Six single nucleotide polymorphisms for potassium channel genes were associated with low-moderate class membership.

Implications for nursing: The results contribute to knowledge of the mechanisms for CRCI. These findings may lead to the identification of high-risk patients and the development of novel therapeutics.

Keywords: attentional function; breast cancer; cancer-related cognitive impairment.

PubMed Disclaimer

Similar articles

See all similar articles

Publication types

Substances