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. 2024 Jun 14;51(4):361-380.
doi: 10.1188/24.ONF.361-380.

Gastrointestinal and Neuropsychological Symptoms Are Associated With Distinct Vomiting Profiles in Patients Receiving Chemotherapy

Komal P Singh  1 , Bruce A Cooper  2 , Steven M Paul  2 , Kathryn Ruddy  3 , Amrit B Singh  4 , Jun Chen  3 , Keenan A Pituch  1 , Tom E Grys  3 , Parminder Singh  5 , Felipe Batalini  3 , Marilyn J Hammer  6 , Jon D Levine  2 , Christine Miaskowski  2
Affiliations

Gastrointestinal and Neuropsychological Symptoms Are Associated With Distinct Vomiting Profiles in Patients Receiving Chemotherapy

Komal P Singh et al. Oncol Nurs Forum. .

Abstract

Objectives: To identify subgroups of patients with distinct chemotherapy-induced vomiting (CIV) profiles; determine how these subgroups differ on several demographic, clinical, and symptom characteristics; and evaluate factors associated with chemotherapy-induced nausea and CIV profiles.

Sample & setting: Adult patients (N = 1,338) receiving cancer chemotherapy.

Methods & variables: Data were collected on demographic, clinical, and symptom characteristics. Differences among subgroups of patients with distinct CIV profiles were evaluated using parametric and nonparametric tests.

Results: Three CIV profiles (None, Decreasing, and Increasing) were identified. Compared with the None class, Decreasing and Increasing classes were more likely to have lower household income and a higher comorbidity burden, as well as to report higher rates of dry mouth, nausea, diarrhea, depression, anxiety, sleep disturbance, morning fatigue, and pain interference.

Implications for nursing: Clinicians need to assess common and distinct risk factors for CIV and chemotherapy-induced nausea.

Keywords: cancer; chemotherapy; latent class analysis; nausea; vomiting.

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