[The clinical relevance of opioid-induced hyperalgesia remains unresolved]
[Article in
Danish]
Affiliations
- PMID: 21453637
Item in Clipboard
[The clinical relevance of opioid-induced hyperalgesia remains unresolved]
[Article in
Danish]
Ugeskr Laeger.
.
Abstract
Opioids are widely used as analgesics in chronic pain of malignant as well as non-malignant origin. During opioid treatment, pain is occasionally worsened. This could be due to progression of the disease or tolerance or opioid-induced hyperalgesia (OIH). The present article summarizes the preclinical and clinical data in support of the existence of OIH. Further, possible mechanisms and potential treatments are outlined. We conclude that only a few clinical studies on OIH are available. However, a growing body of experimental data supports the presence of OIH in clinical settings. Diagnostic tools for assessment of OIH have yet to be developed.
Similar articles
-
Opioid induced hyperalgesia: clinical implications for the pain practitioner.Pain Physician. 2009 May-Jun;12(3):679-84. Pain Physician. 2009. PMID: 19461836 Review.
-
A comprehensive review of opioid-induced hyperalgesia.Pain Physician. 2011 Mar-Apr;14(2):145-61. Pain Physician. 2011. PMID: 21412369 Review.
-
Do opioids induce hyperalgesia in humans? An evidence-based structured review.Pain Med. 2009 Jul-Aug;10(5):829-39. doi: 10.1111/j.1526-4637.2009.00653.x. Epub 2009 Jul 6. Pain Med. 2009. PMID: 19594845 Review.
-
Opioid hyperalgesia.Curr Opin Support Palliat Care. 2010 Mar;4(1):1-5. doi: 10.1097/SPC.0b013e328335ddfe. Curr Opin Support Palliat Care. 2010. PMID: 20019618 Review.
-
Clinical interpretation of opioid tolerance versus opioid-induced hyperalgesia.J Opioid Manag. 2014 Nov-Dec;10(6):383-93. doi: 10.5055/jom.2014.0235. J Opioid Manag. 2014. PMID: 25531956
Cited by
-
Rapid Recovery Pathway for Postoperative Treatment of Adolescent Idiopathic Scoliosis.J Am Acad Orthop Surg Glob Res Rev. 2021 Mar 10;5(3):e20.00220. doi: 10.5435/JAAOSGlobal-D-20-00220. J Am Acad Orthop Surg Glob Res Rev. 2021. PMID: 33720057 Free PMC article.
-
Mechanisms, diagnosis, prevention and management of perioperative opioid-induced hyperalgesia.Pain Manag. 2021 Apr;11(4):405-417. doi: 10.2217/pmt-2020-0105. Epub 2021 Mar 29. Pain Manag. 2021. PMID: 33779215 Free PMC article.