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. 2023 Mar 21:12:58.
doi: 10.4103/abr.abr_222_22. eCollection 2023.

Comparison of the Effect of Preoperative Oral Tizanidine and Pregabalin on Shoulder Pain in Laparoscopic Cholecystectomy Under General Anesthesia

Shahryar Sane  1 , Shahram Sayyadi  2 , Rahman Abbasivash  1 , Seyfollah Rezaei  3 , Ashkan Azadfar  4 , Sohrab Salimi  5
Affiliations

Comparison of the Effect of Preoperative Oral Tizanidine and Pregabalin on Shoulder Pain in Laparoscopic Cholecystectomy Under General Anesthesia

Shahryar Sane et al. Adv Biomed Res. .

Abstract

Background: Shoulder pain is considered as the most important and relatively common postoperative cholecystectomy complications that often controls in recovery room by systemic narcotics that may have some side effects. The aim of this study was to evaluate the effect of premedication with oral tizanidine on shoulder pain relief after elective laparoscopic cholecystectomy.

Materials and methods: In this double-blinded clinical trial, 75 adults of American Society of Anesthesiologist physiologic state 1 and 2 scheduled for elective laparoscopic cholecystectomy under general anesthesia were selected and randomly divided in three groups of T, P, and control groups. Ninety minutes before the induction of anesthesia, patients received either 4 mg tizanidine (T group), 100 mg pregabalin (P group), or orally in 50cc or the same volume of plain water as a placebo (control group). Then, the vital signs, pain intensity, and the need for analgesic were measured during 24 hours and then compared in the groups.

Results: There was no significant difference in patient characteristics, with respect to age, weight, gender, and duration of anesthesia and surgery between the groups (P > 0.05). The pain intensity and need for analgesic were significantly lower in tizanidine and pregabalin groups than the control group (P < 0.003) vs (P < 0.001). There was no significant difference in vital signs characteristics between the groups.

Conclusion: Oral administration of 4 mg tizanidine and 100 mg pregabalin 90 minutes before laparoscopic cholecystectomy significantly relive postoperative shoulder pain and analgesic consumption without any complication.

Keywords: Analgesia; laparoscopic cholecystectomy; pregabalin; shoulder pain; tizanidine.

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Conflict of interest statement

There are no conflicts of interest.

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References

    1. Ahmadyari , Z , Sane Sh. The effect of Tizanidine on postoperative shoulder pain in laparoscopic cholecystectomy with general anesthesia. J Iran Soc Anaesthesiol Crit Care. 2018;40:25–33.
    1. Shoeibi G, Sadeghi M, Atef Yakta R, Esteghamat SS. Analgesic effect of gabapentin compared to tizanidine after elective hysterectomy at Shariati Hospital during 2011-2012. Neurosci J Shefaye Khatam. 2013;1:29–33.
    1. Donatsky AM, Bjerrum F, Gögenur I. Surgical techniques to minimize shoulder pain after laparoscopic cholecystectomy. A systematic review. Surg Endoscop. 2013;27:2275–82. - PubMed
    1. Joshi GP, White PF. Postoperative pain management: Day surgery. In: Rowbotham DJ, McIntyre P, editors. Clinical Pain Management – Acute Pain. London: Arnold; 2003. pp. 329–40.
    1. Alam MS, Hoque HW, Saifullah M, Ali MO. Port site and intraperitoneal infiltration of local anesthetics in reduction of post-operative pain after laparoscopic cholecystectomy. Med Today. 2009;22:24–8.