Abstract
Two groups of beneficial bacteria are dominant in the human gut, the Bacteroidetes and the Firmicutes. Here we show that the relative proportion of Bacteroidetes is decreased in obese people by comparison with lean people, and that this proportion increases with weight loss on two types of low-calorie diet. Our findings indicate that obesity has a microbial component, which might have potential therapeutic implications.
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References
Gill, S. R. et al. Science 312, 1355–1359 (2006).
Backhed, F. et al. Proc. Natl Acad. Sci. USA 101, 15718–15723 (2004).
Ley, R. E. et al. Proc. Natl Acad. Sci. USA 102, 11070–11075 (2005).
Turnbaugh, P. J. et al. Nature 444, 1027–1031 (2006). | Article |
Rawls, J. F., Mahowald, M. A., Ley, R. E. & Gordon, J. I. Cell 127, 423–433 (2006).
Eckburg, P. B. et al. Science 308, 1635–1638 (2005).
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Ley, R., Turnbaugh, P., Klein, S. et al. Human gut microbes associated with obesity. Nature 444, 1022–1023 (2006). https://doi.org/10.1038/4441022a
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DOI: https://doi.org/10.1038/4441022a
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