Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Nov;51(3):880-92.
doi: 10.1007/s12031-013-0095-4. Epub 2013 Aug 23.

Structural and molecular alterations of primary afferent fibres in the spinal dorsal horn in vincristine-induced neuropathy in rat

Karine Thibault  1 , Isabelle Rivals, Saïd M'Dahoma, Sophie Dubacq, Sophie Pezet, Bernard Calvino
Affiliations

Structural and molecular alterations of primary afferent fibres in the spinal dorsal horn in vincristine-induced neuropathy in rat

Karine Thibault et al. J Mol Neurosci. 2013 Nov.

Abstract

Vincristine is one of the most common anti-cancer drug therapies administered for the treatment of many types of cancer. Its dose-limiting side effect is the emergence of peripheral neuropathy, resulting in chronic neuropathic pain in many patients. This study sought to understand the mechanisms underlying the development of neuropathic pain by vincristine-induced neurotoxicity. We focused on signs of functional changes and revealed that deep layers of the spinal cord (III-IV) experience increased neuronal activity both in the absence of peripheral stimulation and, as a result of tactile mechanical stimulations. These laminae and superficial laminae I-II were also subject to structural changes as evidenced by an increase in immunoreactivity of Piccolo, a marker of active presynaptic elements. Further investigations performed, using DNA microarray technology, describe a large number of genes differentially expressed in dorsal root ganglions and in the spinal dorsal horn after vincristine treatment. Our study describes an important list of genes differentially regulated by vincristine treatment that will be useful for future studies and brings forward evidence for molecular and anatomical modifications of large diameter sensory neurons terminating in deep dorsal horn laminae, which could participate in the development of tactile allodynia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Neurochem Int. 2010 Jan;56(1):77-83 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6504-9 - PubMed
    1. Brain Res Mol Brain Res. 2004 May 19;124(2):199-203 - PubMed
    1. Brain Res. 2007 Sep 7;1168:46-59 - PubMed
    1. J Comp Neurol. 2000 Sep 4;424(4):563-76 - PubMed

Publication types

LinkOut - more resources