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Surfing the p53 network

Nature volume 408, pages 307–310 (2000)Cite this article

The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences.

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Figure 1
Figure 2: Viral oncogenes and the p53 network.
Figure 3: The p53 network.

References

  1. Hollstein, M. et al. Mutat. Res. 431, 199– 209 (1999).

    Article  CAS  Google Scholar 

  2. Hussain, S. P. & Harris, C. C. Mutat. Res. 428, 23–32 (1999).

    Article  CAS  Google Scholar 

  3. Carr, A. M. Science 287, 1765–1766 ( 2000).

    Article  CAS  Google Scholar 

  4. Sherr, C. J. & Weber, J. D. Curr. Opin. Genet. Dev. 10, 94–99 (2000).

    Article  CAS  Google Scholar 

  5. Lowe, S. W. & Lin, A. W. Carcinogenesis 21, 485–495 (2000).

    Article  CAS  Google Scholar 

  6. Meek, D. W. Oncogene 18, 7666–7675 ( 1999).

    Article  CAS  Google Scholar 

  7. Momand, J., Wu, H. H. & Dasgupta, G. Gene 242, 15– 29 (2000).

    Article  CAS  Google Scholar 

  8. Prives, C. & Hall, P. A. J. Pathol. 187, 112–126 (1999).

    Article  CAS  Google Scholar 

  9. Giaccia, A. J. & Kastan, M. B. Genes Dev. 12, 2973–2983 (1998).

    Article  CAS  Google Scholar 

  10. Selivanova, G., Kawasaki, T., Ryabchenko, L. & Wiman, K. G. Semin. Cancer Biol. 8, 369–378 (1998).

    Article  CAS  Google Scholar 

  11. Buschmann, T., Fuchs, S. Y., Lee, C. G., Pan, Z. Q. & Ronai, Z. Cell 101, 753– 762 (2000).

    Article  CAS  Google Scholar 

  12. Bar-Or, R. L. et al. Proc. Natl Acad. Sci. USA 97, 11250 –11255 (2000).

    Article  ADS  CAS  Google Scholar 

  13. Lozano, G. & Liu, G. Semin. Cancer Biol. 8, 337–344 (1998).

    Article  CAS  Google Scholar 

  14. Bell, D. W. et al. Science 286, 2528– 2531 (1999).

    Article  CAS  Google Scholar 

  15. Vousden, H. & Van de Woude, G. F. Nature Cell Biol. 2, E178–E180 (2000).

    Article  CAS  Google Scholar 

  16. Levine, A. J. Cell 88, 323–331 ( 1997).

    Article  CAS  Google Scholar 

  17. El-Deiry, W. S. Semin. Cancer Biol. 8, 345–357 (1998).

    Article  CAS  Google Scholar 

  18. Ohki, R. et al. J. Biol. Chem. 275, 22627– 22630 (2000).

    Article  CAS  Google Scholar 

  19. Chan, T. A. et al. Nature 401, 616–620 (1999).

    Article  ADS  CAS  Google Scholar 

  20. Laronga, C. et al. J. Biol. Chem. 275, 23106– 23112 (2000).

    Article  CAS  Google Scholar 

  21. Dellambra, E. et al. J. Cell Biol. 149, 1117– 1130 (2000).

    Article  CAS  Google Scholar 

  22. Gottlieb, T. M. & Oren, M. Semin. Cancer Biol. 8, 359–368 ( 1998).

    Article  CAS  Google Scholar 

  23. Reed, J. C. J. Clin. Oncol. 17, 2941–2953 (1999).

    Article  CAS  Google Scholar 

  24. Schmidt, T. et al. Cell Death Differ. 6, 873– 882 (1999).

    Article  CAS  Google Scholar 

  25. Oda, E. et al. Science 288, 1053–1058 (2000).

    Article  ADS  CAS  Google Scholar 

  26. Oda, K. et al. Cell 102, 849–862 (2000).

    Article  CAS  Google Scholar 

  27. Lin, Y., Ma, W. & Benchimol, S. Nature Genet. 26, 122– 127 (2000).

    Article  CAS  Google Scholar 

  28. Tlsty, T. D. Curr. Top. Microbiol. Immunol. 221, 37– 46 (1997).

    CAS  PubMed  Google Scholar 

  29. Wahl, G. M. et al. Cancer Surv. 29, 183– 219 (1997).

    CAS  PubMed  Google Scholar 

  30. Tanaka, H. et al. Nature 404, 42–49 (2000).

    Article  ADS  CAS  Google Scholar 

  31. Lozano, G. & Elledge, S. J. Nature 404, 24–25 (2000).

    Article  CAS  Google Scholar 

  32. Hendrix, M. J. Nature Med. 6, 374–376 ( 2000).

    Article  CAS  Google Scholar 

  33. Schwarte-Waldhoff, I. et al. Proc. Natl Acad. Sci. USA 97, 9624– 9629 (2000).

    Article  ADS  CAS  Google Scholar 

  34. Yu, J. et al. Proc. Natl Acad. Sci. USA 96, 14517– 14522 (1999).

    Article  ADS  CAS  Google Scholar 

  35. Zhao, R. et al. Genes Dev. 14, 981–993 (2000).

    Article  CAS  Google Scholar 

  36. Albert, R. et al. Nature 406, 378–382 (2000).

    Article  ADS  CAS  Google Scholar 

  37. Tu, Y. Nature 406, 353–354 ( 2000).

    Article  ADS  CAS  Google Scholar 

  38. Dotto, G. P. Crit. Rev. Oral Biol. Med. 10, 442– 457 (1999).

    Article  CAS  Google Scholar 

  39. Jones, J. M. et al. Cell Growth Differ. 10, 213– 222 (1999).

    CAS  PubMed  Google Scholar 

  40. Franklin, D. S. et al. Mol. Cell Biol. 20, 6147– 6158 (2000).

    Article  CAS  Google Scholar 

  41. Lamont, J. P. et al. Ann. Surg. Oncol. 7, 588– 592 (2000).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. The Howard Hughes Medical Institute and Johns Hopkins Oncology Center, Baltimore, 21231, Maryland , USA

    Bert Vogelstein

  2. Department of Surgery and Molecular Oncology, Ninewells Hospital, University of Dundee, Dundee, DD1 5EH, UK

    David Lane

  3. Laboratory of Cancer Biology, Genetics, and Molecular Biophysics, Rockefeller University, 1230 York Avenue, New York, 10021 , New York, USA

    Arnold J. Levine

Authors
  1. Bert Vogelstein
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  2. David Lane
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  3. Arnold J. Levine
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Corresponding authors

Correspondence to Bert Vogelstein, David Lane or Arnold J. Levine.

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Vogelstein, B., Lane, D. & Levine, A. Surfing the p53 network. Nature 408, 307–310 (2000). https://doi.org/10.1038/35042675

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