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Mental health: Depression needs large human-genetics studies

To understand the molecular mechanisms of depression, collect genetic data from more than 100,000 people, says Steven Hyman.

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References

  1. Trivedi, M. H. et al. Am. J. Psychiatry 163, 28–40 (2006).

    Article  Google Scholar 

  2. Hyman, S. E. Sci. Transl. Med. 4, 155cm11 (2012).

    Article  Google Scholar 

  3. Sullivan, P. F., Daly, M. J. & O'Donovan, M. Nature Rev. Genet. 13, 537–551 (2012).

    Article  CAS  Google Scholar 

  4. Schizophrenia Working Group of the Psychiatric Genomics Consortium Nature 511, 421–427 (2014).

  5. Duncan, L E. & Keller, M. C. Am. J. Psychiatry 168, 1041–1049 (2011).

    Article  Google Scholar 

  6. Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium Mol. Psychiatry 18, 497–511 (2013).

  7. Levinson, D. F. et al. Biol. Psychiatry 76, 510–512 (2014).

    Article  Google Scholar 

  8. Wood, A. R. et al. Nature Genet. http://dx.doi.org/10.1038/ng.3097 (2014).

  9. Jamain, S. et al. Nature Genet. 34, 27–29 (2003).

    Article  CAS  Google Scholar 

  10. Cross-Disorder Group of the Psychiatric Genomics Consortium Nature Genet. 45, 984–994 (2013).

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Correspondence to Steven Hyman.

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Hyman, S. Mental health: Depression needs large human-genetics studies. Nature 515, 189–191 (2014). https://doi.org/10.1038/515189a

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