Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

doi:10.3390/ijms22179257

Review

. 2021 Aug 26;22(17):9257.

doi: 10.3390/ijms22179257.

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

Chih-Hung Tsai^{1

2}, Yuan-Ho Lin^{1

3}, Yung-Sheng Li^{1

4}, Trung-Loc Ho⁵, Le Huynh Hoai Thuong⁵, Yu-Huei Liu^{1

6

7}

Affiliations

¹ Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan.
² Department of Neurology, National Taiwan University Hospital Yunlin Branch, Yunlin 64041, Taiwan.
³ Department of Chinese Medicine of E-Da Cancer Hospital, Kaohsiung 82445, Taiwan.
⁴ Department of Chinese Medicine of Jiannren Hospital, Kaohsiung 811504, Taiwan.
⁵ International Master's Program of Biomedical Sciences, China Medical University, Taichun 40402, Taiwan.
⁶ Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
⁷ Drug Development Center, China Medical University, Taichung 40402, Taiwan.

PMID: 34502166
PMCID: PMC8430591
DOI: 10.3390/ijms22179257

Review

Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

Chih-Hung Tsai et al. Int J Mol Sci. 2021.

. 2021 Aug 26;22(17):9257.

doi: 10.3390/ijms22179257.

Authors

Chih-Hung Tsai^{1

2}, Yuan-Ho Lin^{1

3}, Yung-Sheng Li^{1

4}, Trung-Loc Ho⁵, Le Huynh Hoai Thuong⁵, Yu-Huei Liu^{1

6

7}

Affiliations

¹ Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan.
² Department of Neurology, National Taiwan University Hospital Yunlin Branch, Yunlin 64041, Taiwan.
³ Department of Chinese Medicine of E-Da Cancer Hospital, Kaohsiung 82445, Taiwan.
⁴ Department of Chinese Medicine of Jiannren Hospital, Kaohsiung 811504, Taiwan.
⁵ International Master's Program of Biomedical Sciences, China Medical University, Taichun 40402, Taiwan.
⁶ Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
⁷ Drug Development Center, China Medical University, Taichung 40402, Taiwan.

PMID: 34502166
PMCID: PMC8430591
DOI: 10.3390/ijms22179257

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of typical chemotherapeutics among cancer survivors. Despite the recent progress, the effective prevention and treatment strategies for CIPN remain limited. Better understanding of the pathogenesis of CIPN may provide new niches for developing a new ideal therapeutic strategy. This review summarizes the current understanding of CIPN and current recommendations along with completed/active clinical trials and aims to foster translational research to improve the development of effective strategies for managing CIPN.

Keywords: alternative and complimentary medicines; cancer survivors; chemotherapy-induced peripheral neuropathy; new drug development.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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References

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1. Gewandter J.S., Fan L., Magnuson A., Mustian K., Peppone L., Heckler C., Hopkins J., Tejani M., Morrow G.R., Mohile S.G. Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): A University of Rochester CCOP study. Support. Care Cancer. 2013;21:2059–2066. doi: 10.1007/s00520-013-1766-y. - DOI - PMC - PubMed
1. Dorsey S.G., Kleckner I.R., Barton D., Mustian K., O’Mara A., Germain D.S., Cavaletti G., Danhauer S.C., Hershman D.L., Hohmann A.G., et al. The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy. J. Natl. Cancer Inst. 2019;111:531–537. doi: 10.1093/jnci/djz011. - DOI - PMC - PubMed
1. Gadgil S., Ergün M., Heuvel S.A.V.D., van der Wal S.E., Scheffer G.J., Hooijmans C.R. A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN) PLoS ONE. 2019;14:e0221787. doi: 10.1371/journal.pone.0221787. - DOI - PMC - PubMed
1. Kanzawa-Lee G.A., Knoerl R., Donohoe C., Bridges C.M., Smith E.M.L. Mechanisms, predictors, and challenges in assessing and managing painful chemotherapy-induced peripheral neuropathy. Semin. Oncol. Nurs. 2019;35:253–260. doi: 10.1016/j.soncn.2019.04.006. - DOI - PMC - PubMed

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[1] Winters-Stone K.M., Horak F., Jacobs P.G., Trubowitz P., Dieckmann N., Stoyles S., Faithfull S. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J. Clin. Oncol. 2017;35:2604–2612. doi: 10.1200/JCO.2016.71.3552. - DOI - PMC - PubMed

[2] Winters-Stone K.M., Horak F., Jacobs P.G., Trubowitz P., Dieckmann N., Stoyles S., Faithfull S. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J. Clin. Oncol. 2017;35:2604–2612. doi: 10.1200/JCO.2016.71.3552. - DOI - PMC - PubMed

[3] Gewandter J.S., Fan L., Magnuson A., Mustian K., Peppone L., Heckler C., Hopkins J., Tejani M., Morrow G.R., Mohile S.G. Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): A University of Rochester CCOP study. Support. Care Cancer. 2013;21:2059–2066. doi: 10.1007/s00520-013-1766-y. - DOI - PMC - PubMed

[4] Gewandter J.S., Fan L., Magnuson A., Mustian K., Peppone L., Heckler C., Hopkins J., Tejani M., Morrow G.R., Mohile S.G. Falls and functional impairments in cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN): A University of Rochester CCOP study. Support. Care Cancer. 2013;21:2059–2066. doi: 10.1007/s00520-013-1766-y. - DOI - PMC - PubMed

[5] Dorsey S.G., Kleckner I.R., Barton D., Mustian K., O’Mara A., Germain D.S., Cavaletti G., Danhauer S.C., Hershman D.L., Hohmann A.G., et al. The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy. J. Natl. Cancer Inst. 2019;111:531–537. doi: 10.1093/jnci/djz011. - DOI - PMC - PubMed

[6] Dorsey S.G., Kleckner I.R., Barton D., Mustian K., O’Mara A., Germain D.S., Cavaletti G., Danhauer S.C., Hershman D.L., Hohmann A.G., et al. The national cancer institute clinical trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy. J. Natl. Cancer Inst. 2019;111:531–537. doi: 10.1093/jnci/djz011. - DOI - PMC - PubMed

[7] Gadgil S., Ergün M., Heuvel S.A.V.D., van der Wal S.E., Scheffer G.J., Hooijmans C.R. A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN) PLoS ONE. 2019;14:e0221787. doi: 10.1371/journal.pone.0221787. - DOI - PMC - PubMed

[8] Gadgil S., Ergün M., Heuvel S.A.V.D., van der Wal S.E., Scheffer G.J., Hooijmans C.R. A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN) PLoS ONE. 2019;14:e0221787. doi: 10.1371/journal.pone.0221787. - DOI - PMC - PubMed

[9] Kanzawa-Lee G.A., Knoerl R., Donohoe C., Bridges C.M., Smith E.M.L. Mechanisms, predictors, and challenges in assessing and managing painful chemotherapy-induced peripheral neuropathy. Semin. Oncol. Nurs. 2019;35:253–260. doi: 10.1016/j.soncn.2019.04.006. - DOI - PMC - PubMed

[10] Kanzawa-Lee G.A., Knoerl R., Donohoe C., Bridges C.M., Smith E.M.L. Mechanisms, predictors, and challenges in assessing and managing painful chemotherapy-induced peripheral neuropathy. Semin. Oncol. Nurs. 2019;35:253–260. doi: 10.1016/j.soncn.2019.04.006. - DOI - PMC - PubMed

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Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

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Integrated Medicine for Chemotherapy-Induced Peripheral Neuropathy

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