The Crew Dragon Endurance will splash down in the ocean with the Crew-10 mission composed of NASA astronauts commander Anne McClain and pilot Nichole Ayes, and mission specialists Takuya Onishi of Japan's JAXA and Kirill Peskov of Russia's Roscosmos, after a six-month stay on the ISS.

ESA's Juice spacecraft will perform a gravity assist utilizing Venus's gravity to alter its path and speed.

Tianwen-2 will rendezvous with Kamo'oalewa and collect samples from the asteroid, which will later be returned to Earth. Unconfirmed mission timeline, target may differ from July 2026.

JAXA's Hayabusa2 spacecraft will fly by the near-Earth asteroid Torifune (2001 CC21). Hayabusa2 will approach within 100 km (62 mi) of Torifune at a relative speed of 5 km/s (3.1 mi/s).

ESA's Juice spacecraft will perform a gravity assist utilizing Earth's gravity to alter its path and speed.

BepiColombo will perform a burn to insert itself into an orbit around Mercury. Shortly after arriving at the planet, BepiColombo will begin studying the composition, geophysics, atmosphere, magnetosphere, and history of Mercury.

NASA's Europa Clipper spacecraft will perform a gravity assist utilizing Earth's gravity to alter its path and speed.

NASA's Lucy spacecraft will fly by the asteroid 3548 Eurybates, a Jupiter trojan, and its satellite Queta. Lucy will approach the asteroid to a distance of 1000 km (620 mi) at a relative velocity of 5.8 km/s (13,000 mph).

NASA's Lucy spacecraft will fly by the Jupiter Trojan 15094 Polymele and its unnamed satellite. Lucy will approach the asteroid to a distance of 415 km (258 mi) at a relative velocity of 6 km/s (~13,400 mph).

Tianwen-2 will separate a capsule containing samples collected from asteroid Kamo'oalewa, which will re-enter the Earth's atmosphere and be collected. Unconfirmed mission timeline, target may differ from November 2027.

JAXA's Hayabusa2 spacecraft will perform its 3rd Earth gravity assist, utilizing Earth's gravity to alter its path and speed.

NASA's Lucy spacecraft will fly by the Jupiter Trojan 11351 Leucus, an exceptionally slowly rotating asteroid with a rotation period of 466 hours. Lucy will approach the asteroid to a distance of 1,000 km (620 mi) at a relative velocity of 5.9 km/s (~13,200 mph).

JAXA's Hayabusa2 spacecraft will perform its 4th Earth gravity assist, utilizing Earth's gravity to alter its path and speed.

NASA's Lucy spacecraft will fly by the Jupiter Trojan 21900 Orus, one of the 100 largest Jupiter trojans. Lucy will approach the asteroid to a distance of 1000 km (620 mi) at a relative velocity of 7.1 km/s (~15,900 mph).

ESA's Juice spacecraft will perform another gravity assist utilizing Earth's gravity to alter its path and speed.

OSIRIS-APEX, a follow-on to OSIRIS-REx, will study the physical changes to near-Earth asteroid Apophis a few days after the asteroid performs a close approach with Earth.

Asteroid Psyche’s gravity will capture the spacecraft in late July 2029, and Psyche will begin its mission in August. It will spend about two years orbiting the asteroid to take pictures, map the surface, and collect data to determine Psyche’s composition.

NASA's Europa Clipper will use its engines as brakes to slow the spacecraft down to match Jupiter's orbit, performing a flyby of Ganymede during this process.

NASA's Lucy spacecraft will perform a gravity assist utilizing Earth's gravity to alter its path and speed. First time a spacecraft will return to Earth from beyond Jupiter's orbit.

Hayabusa2 will rendezvous with 1998 KY26, making the asteroid the smallest to be studied by a spacecraft at only around 30 meters (~100 ft) in diameter. 1998 KY26 will also be the first fast rotator asteroid to be studied by a spacecraft, with a rotational period of 10.7 minutes.

ESA's Juice spacecraft will enter an orbit around Jupiter, using a flyby by Ganymede to reduce velocity in addition to an insertion burn by the spacecraft. While at Jupiter, Juice will perform numerous flybys to study Ganymede, Callisto, and Europa.

NASA's Lucy spacecraft will fly by the binary asteroid pair Patroclus and Menoetius. Both asteroids are similarly sized and are some of the largest Trojan asteroids. Lucy will approach the asteroids to a distance of 1000 km (620 mi) at a relative velocity of 8.8 km/s (~19,700 mph).

ESA's Juice spacecraft will perform a braking burn to enter an orbit around Ganymede. While orbiting, the spacecraft will study Ganymede's unique magnetosphere, as well as the atmosphere, surface, subsurface, interior, and internal ocean of the Jovian moon.

Tianwen-2 will enter an orbit around and begin studying 311P/PanSTARRS, an object with an asteroid-like orbit but with comet-like visual characteristics. Unconfirmed mission timeline, target may differ from January 2035.