Chemotherapy-Related Neurotoxicity

doi:10.1007/s11910-016-0686-x

Review

. 2016 Sep;16(9):81.

doi: 10.1007/s11910-016-0686-x.

Chemotherapy-Related Neurotoxicity

Sophie Taillibert¹, Emilie Le Rhun^{2

3

4}, Marc C Chamberlain⁵

Affiliations

¹ Department of Neurology 2. Pitié-Salpétrière Hospital, Assistance Publique des Hôpitaux de Paris (APHP), University Pierre and Marie Curie, Paris VI, Paris, France.
² Neuro-oncology, Neurosurgery Department, University Hospital, Lille, France.
³ Neurology, Medical Oncology Department, Oscar Lambret Center, Lille, France.
⁴ Lille University, INSERM U1192, Villeneuve d'Ascq, France.
⁵ Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Ave E, Seattle, WA, 98109, USA. [email protected].

PMID: 27443648
DOI: 10.1007/s11910-016-0686-x

Review

Chemotherapy-Related Neurotoxicity

Sophie Taillibert et al. Curr Neurol Neurosci Rep. 2016 Sep.

. 2016 Sep;16(9):81.

doi: 10.1007/s11910-016-0686-x.

Authors

Sophie Taillibert¹, Emilie Le Rhun^{2

3

4}, Marc C Chamberlain⁵

Affiliations

¹ Department of Neurology 2. Pitié-Salpétrière Hospital, Assistance Publique des Hôpitaux de Paris (APHP), University Pierre and Marie Curie, Paris VI, Paris, France.
² Neuro-oncology, Neurosurgery Department, University Hospital, Lille, France.
³ Neurology, Medical Oncology Department, Oscar Lambret Center, Lille, France.
⁴ Lille University, INSERM U1192, Villeneuve d'Ascq, France.
⁵ Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington, 825 Eastlake Ave E, Seattle, WA, 98109, USA. [email protected].

PMID: 27443648
DOI: 10.1007/s11910-016-0686-x

Abstract

Chemotherapy may have detrimental effects on either the central or peripheral nervous system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a wide range of clinical syndromes including acute, subacute, and chronic encephalopathies, posterior reversible encephalopathy, acute cerebellar dysfunction, chronic cognitive impairment, myelopathy, meningitis, and neurovascular syndromes. These clinical entities vary by causative agent, degree of severity, evolution, and timing of occurrence. In the peripheral nervous system, chemotherapy-induced peripheral neuropathy (CIPN) and myopathy are the two main complications of chemotherapy. CIPN is the most common complication, and the majority manifest as a dose-dependent length-dependent sensory axonopathy. In severe cases of CIPN, the dose of chemotherapy is reduced, the administration delayed, or the treatment discontinued. Few treatments are available for CIPN and based on meta-analysis, duloxetine is the preferred symptomatic treatment. Myopathy due to corticosteroid use is the most frequent cause of muscle disorders in patients with cancer.

Keywords: Chemobrain; Chemotherapy; Chemotherapy-induced peripheral neuropathy; Encephalopathy; Myopathy; Neurotoxicity.

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[1] J Neurol. 2011 Sep;258(9):1729-31 - PubMed

[2] J Neurol. 2011 Sep;258(9):1729-31 - PubMed

[3] J Clin Oncol. 2014 Jul 1;32(19):2031-8 - PubMed

[4] J Clin Oncol. 2014 Jul 1;32(19):2031-8 - PubMed

[5] Cochrane Database Syst Rev. 2015 Aug 23;(8):CD011091 - PubMed

[6] Cochrane Database Syst Rev. 2015 Aug 23;(8):CD011091 - PubMed

[7] Ann Oncol. 2011 Aug;22(8):1763-9 - PubMed

[8] Ann Oncol. 2011 Aug;22(8):1763-9 - PubMed

[9] J Clin Oncol. 2006 Sep 20;24(27):4507-14 - PubMed

[10] J Clin Oncol. 2006 Sep 20;24(27):4507-14 - PubMed

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Chemotherapy-Related Neurotoxicity

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Chemotherapy-Related Neurotoxicity

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