Chemotherapy-Related Neurotoxicity
- PMID: 27443648
- DOI: 10.1007/s11910-016-0686-x
Chemotherapy-Related Neurotoxicity
Abstract
Chemotherapy may have detrimental effects on either the central or peripheral nervous system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a wide range of clinical syndromes including acute, subacute, and chronic encephalopathies, posterior reversible encephalopathy, acute cerebellar dysfunction, chronic cognitive impairment, myelopathy, meningitis, and neurovascular syndromes. These clinical entities vary by causative agent, degree of severity, evolution, and timing of occurrence. In the peripheral nervous system, chemotherapy-induced peripheral neuropathy (CIPN) and myopathy are the two main complications of chemotherapy. CIPN is the most common complication, and the majority manifest as a dose-dependent length-dependent sensory axonopathy. In severe cases of CIPN, the dose of chemotherapy is reduced, the administration delayed, or the treatment discontinued. Few treatments are available for CIPN and based on meta-analysis, duloxetine is the preferred symptomatic treatment. Myopathy due to corticosteroid use is the most frequent cause of muscle disorders in patients with cancer.
Keywords: Chemobrain; Chemotherapy; Chemotherapy-induced peripheral neuropathy; Encephalopathy; Myopathy; Neurotoxicity.
Similar articles
-
Chemotherapy-induced peripheral neurotoxicity.Curr Opin Neurol. 2015 Oct;28(5):500-7. doi: 10.1097/WCO.0000000000000234. Curr Opin Neurol. 2015. PMID: 26197027 Review.
-
A prospective surveillance model for physical rehabilitation of women with breast cancer: chemotherapy-induced peripheral neuropathy.Cancer. 2012 Apr 15;118(8 Suppl):2250-60. doi: 10.1002/cncr.27463. Cancer. 2012. PMID: 22488699 Review.
-
A randomised, placebo-controlled trial assessing the efficacy of an oral B group vitamin in preventing the development of chemotherapy-induced peripheral neuropathy (CIPN).Support Care Cancer. 2017 Jan;25(1):195-204. doi: 10.1007/s00520-016-3404-y. Epub 2016 Sep 9. Support Care Cancer. 2017. PMID: 27612466 Clinical Trial.
-
Toxic neuropathies: Chemotherapy Induced Peripheral Neurotoxicity.Curr Opin Neurol. 2019 Oct;32(5):676-683. doi: 10.1097/WCO.0000000000000724. Curr Opin Neurol. 2019. PMID: 31306214 Review.
-
Chemotherapy-induced peripheral neuropathy (CIPN) and its treatment: an NIH Collaboratory study of claims data.Support Care Cancer. 2020 Jun;28(6):2553-2562. doi: 10.1007/s00520-019-05063-x. Epub 2019 Sep 7. Support Care Cancer. 2020. PMID: 31494735 Free PMC article.
Cited by
-
Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways.Front Physiol. 2016 Oct 19;7:472. doi: 10.3389/fphys.2016.00472. eCollection 2016. Front Physiol. 2016. PMID: 27807421 Free PMC article.
-
Role of inflammation and oxidative stress in chemotherapy-induced neurotoxicity.Immunol Res. 2022 Dec;70(6):725-741. doi: 10.1007/s12026-022-09307-7. Epub 2022 Jul 20. Immunol Res. 2022. PMID: 35859244 Review.
-
Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro.Integr Cancer Ther. 2018 Jun;17(2):542-550. doi: 10.1177/1534735417740630. Epub 2017 Nov 21. Integr Cancer Ther. 2018. PMID: 29161917 Free PMC article.
-
Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization.Drug Des Devel Ther. 2023 Apr 12;17:1125-1138. doi: 10.2147/DDDT.S400936. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37077409 Free PMC article.
-
Toward better understanding and management of chemobrain: the potential utilities of the MemTrax memory test.BMC Womens Health. 2024 Jul 17;24(1):406. doi: 10.1186/s12905-024-03251-4. BMC Womens Health. 2024. PMID: 39020328 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical