Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

doi:10.1186/s12885-021-07793-w

. 2021 Jan 27;21(1):99.

doi: 10.1186/s12885-021-07793-w.

Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

Yacir El Alami^{1

2

3}, Hajar Essangri^{1

2}, Mohammed Anass Majbar^{1

2}, Saber Boutayeb^{1

2}, Said Benamr^{1

2}, Hadj Omar El Malki^{2

4

5

6}, Amine Souadka^{7

8}

Affiliations

¹ The Surgical Department, National Institute of Oncology, Rabat, Morocco.
² Faculty Of Medicine Of Rabat, Mohammed V University, Rabat, Morocco.
³ The Doctoral School of Life and Health Sciences, Mohammed V University, (CEDOC SVS), Rabat, Morocco.
⁴ The Surgical Department 'A', Ibn Sina Hospital, Rabat, Morocco.
⁵ The Laboratory of Clinical Research and Epidemiology of Mohammed V University, Rabat, Morocco.
⁶ Abulcasis International University of Health Sciences, Rabat, Morocco.
⁷ The Surgical Department, National Institute of Oncology, Rabat, Morocco. [email protected].
⁸ Faculty Of Medicine Of Rabat, Mohammed V University, Rabat, Morocco. [email protected].

PMID: 33499819
PMCID: PMC7839186
DOI: 10.1186/s12885-021-07793-w

Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

Yacir El Alami et al. BMC Cancer. 2021.

. 2021 Jan 27;21(1):99.

doi: 10.1186/s12885-021-07793-w.

Authors

Yacir El Alami^{1

2

3}, Hajar Essangri^{1

2}, Mohammed Anass Majbar^{1

2}, Saber Boutayeb^{1

2}, Said Benamr^{1

2}, Hadj Omar El Malki^{2

4

5

6}, Amine Souadka^{7

8}

Affiliations

¹ The Surgical Department, National Institute of Oncology, Rabat, Morocco.
² Faculty Of Medicine Of Rabat, Mohammed V University, Rabat, Morocco.
³ The Doctoral School of Life and Health Sciences, Mohammed V University, (CEDOC SVS), Rabat, Morocco.
⁴ The Surgical Department 'A', Ibn Sina Hospital, Rabat, Morocco.
⁵ The Laboratory of Clinical Research and Epidemiology of Mohammed V University, Rabat, Morocco.
⁶ Abulcasis International University of Health Sciences, Rabat, Morocco.
⁷ The Surgical Department, National Institute of Oncology, Rabat, Morocco. [email protected].
⁸ Faculty Of Medicine Of Rabat, Mohammed V University, Rabat, Morocco. [email protected].

PMID: 33499819
PMCID: PMC7839186
DOI: 10.1186/s12885-021-07793-w

Abstract

Background: Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the validity and reliability of the Moroccan Arabic Dialectal version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) in patients with colorectal cancer.

Methods: We conducted a cross-sectional study using the Moroccan version of the EORTC QLQ-C30 on colorectal cancer patients from the National Oncology Institute of Rabat, in the period from February 2015 to June 2017. The QLQ-C30 was administered to 120 patients. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons.

Results: In total, 120 patients with colorectal cancer were included in the study with 38 (32%) patients diagnosed with colon cancers. Eighty-two patients (68%) had rectal cancer, among which 29 (24%) patients with a stoma. The mean age of diagnosis was 54 years (+/- 13.3). The reliability and validity of the Arabic dialectal Moroccan version of the EORTC QLQ-C30 were satisfactory. [Cronbach's alpha (α =0.74)]. All items accomplished the criteria for convergent and discriminant validity except for question number 5, which did not complete the minimum required correlation with its own scale (physical functioning). Patients with rectal cancer presented with bad Global health status and quality of life (GHS/QOL), emotional functioning as well as higher fatigue symptoms compared to patients with colon cancer. The difference between patients with and without stoma was significant for diarrhea and financial difficulty.

Conclusions: The Moroccan Arabic Dialectal version of the QLQ-C30 is a valid and reliable measure of health-related quality of life (HRQOL) in patients with colorectal cancer.

Keywords: Colonic neoplasms patient-reported outcome; EORTC QLQ-C30; Morocco; Rectal neoplasm; Validation.

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Conflict of interest statement

The authors declare not having competing interests.

Figures

**Fig. 1**
Flowchart of the literature review search on The EORTC QLQ-C30 validation studies

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References

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1. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute. 1993;85:365–376. doi: 10.1093/jnci/85.5.365. - DOI - PubMed
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[1] LeBlanc TW, Abernethy AP. Patient-reported outcomes in cancer care - hearing the patient voice at greater volume. Nat Rev Clin Oncol. 2017;14:763–772. doi: 10.1038/nrclinonc.2017.153. - DOI - PubMed

[2] LeBlanc TW, Abernethy AP. Patient-reported outcomes in cancer care - hearing the patient voice at greater volume. Nat Rev Clin Oncol. 2017;14:763–772. doi: 10.1038/nrclinonc.2017.153. - DOI - PubMed

[3] Hwang TJ, Gyawali B. Association between progression-free survival and patients’ quality of life in cancer clinical trials. Int J Cancer. 2019;144:1746–1751. doi: 10.1002/ijc.31957. - DOI - PubMed

[4] Hwang TJ, Gyawali B. Association between progression-free survival and patients’ quality of life in cancer clinical trials. Int J Cancer. 2019;144:1746–1751. doi: 10.1002/ijc.31957. - DOI - PubMed

[5] Ebrahim S. Clinical and public health perspectives and applications of health-related quality of life measurement. Soc Sci Med. 1995;41:1383–1394. doi: 10.1016/0277-9536(95)00116-O. - DOI - PubMed

[6] Ebrahim S. Clinical and public health perspectives and applications of health-related quality of life measurement. Soc Sci Med. 1995;41:1383–1394. doi: 10.1016/0277-9536(95)00116-O. - DOI - PubMed

[7] Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute. 1993;85:365–376. doi: 10.1093/jnci/85.5.365. - DOI - PubMed

[8] Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute. 1993;85:365–376. doi: 10.1093/jnci/85.5.365. - DOI - PubMed

[9] Petersen MA, Groenvold M, Aaronson N, Fayers P, Sprangers M, Bjorner JB, et al. Multidimensional computerized adaptive testing of the EORTC QLQ-C30: basic developments and evaluations. Qual Life Res. 2006;15:315–329. doi: 10.1007/s11136-005-3214-z. - DOI - PubMed

[10] Petersen MA, Groenvold M, Aaronson N, Fayers P, Sprangers M, Bjorner JB, et al. Multidimensional computerized adaptive testing of the EORTC QLQ-C30: basic developments and evaluations. Qual Life Res. 2006;15:315–329. doi: 10.1007/s11136-005-3214-z. - DOI - PubMed

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Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

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Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

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Abstract

Conflict of interest statement

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