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. 1994 Feb 1;6(2):230-6.
doi: 10.1111/j.1460-9568.1994.tb00265.x.

trkC-like immunoreactivity in the primate descending serotoninergic system

U Arvidsson  1 , M Risling, J Frisén, F Piehl, K Fried, T Hökfelt, S Cullheim
Affiliations

trkC-like immunoreactivity in the primate descending serotoninergic system

U Arvidsson et al. Eur J Neurosci. .

Abstract

In the search for substances with a potential role in plastic responses of spinal motoneurons we have studied the distribution of trkC-like immunoreactivity in the spinal cord of adult monkeys (Macaca fascicularis). The presence of trkC, which is a signal-transducing receptor for neurotrophin-3, was detected by the use of indirect immunofluorescence with a rabbit polyclonal antibody raised against a synthetic peptide corresponding to the carboxy-terminal domain of the mouse trkC-encoded protein, thus detecting only full-length signal-transducing receptors. trkC-immunoreactive fibres/varicosities could be found at all spinal cord levels and the densest innervation was found in the autonomic intermediolateral and Onuf's nuclei, but somatic motoneuron pools also received a significant contribution of trkC-immunoreactive fibres. Terminals immunoreactive for trkC were also seen in the dorsal horn. Double-labelling experiments revealed a high degree of coexistence between trkC- and 5-hydroxytryptamine (serotonin)-like immunoreactivity in all areas except in the dorsal horn. The results of the present study suggest that neurotrophic signalling with an influence on serotoninergic as well as non-serotoninergic inputs to the adult monkey spinal cord is at hand.

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