The role of axonal ion conductances in diabetic neuropathy: a review
- PMID: 9736052
- DOI: 10.1002/(sici)1097-4598(199810)21:10<1246::aid-mus2>3.0.co;2-b
The role of axonal ion conductances in diabetic neuropathy: a review
Abstract
Diabetic neuropathy is a common complication in diabetes mellitus. Diabetic neuropathy is accompanied by alterations in axonal excitability, which can lead to either "positive" (paresthesia, dysesthesia, pain) and/or "negative" (hypesthesia, anesthesia) symptoms. The mechanisms underlying these alterations in axonal excitability are not well understood. Clinical tests reveal reduced nerve conduction velocity and axonal loss, but fail to explain nerve excitability. Many different factors have been suggested in relation to the pathophysiology of diabetic neuropathy. There are probably as many factors as there are different clinical pictures in diabetic neuropathy. Nevertheless, it seems that hyperglycemic hypoxia is mainly responsible for the electrophysiological changes seen in damaged diabetic nerves. This article summarizes experimental data indicating that a dysfunction of ion conductances, especially voltage-gated ion channels, could contribute to abnormalities in the generation and/or conduction of action potentials in diabetic neuropathy.
Similar articles
-
Intra-axonal recording from large sensory myelinated axons: demonstration of impaired membrane conductances in early experimental diabetes.Diabetologia. 2003 Feb;46(2):213-21. doi: 10.1007/s00125-002-1026-z. Epub 2003 Feb 18. Diabetologia. 2003. PMID: 12627320
-
Uncovering sensory axonal dysfunction in asymptomatic type 2 diabetic neuropathy.PLoS One. 2017 Feb 9;12(2):e0171223. doi: 10.1371/journal.pone.0171223. eCollection 2017. PLoS One. 2017. PMID: 28182728 Free PMC article.
-
In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes.Clin Neurophysiol. 2016 Feb;127(2):1700-1706. doi: 10.1016/j.clinph.2015.11.047. Epub 2015 Dec 10. Clin Neurophysiol. 2016. PMID: 26725257
-
Axonal ionic pathophysiology in human peripheral neuropathy and motor neuron disease.Curr Neurovasc Res. 2004 Oct;1(4):373-9. doi: 10.2174/1567202043362162. Curr Neurovasc Res. 2004. PMID: 16181085 Review.
-
Axonal ion channels from bench to bedside: a translational neuroscience perspective.Prog Neurobiol. 2009 Nov;89(3):288-313. doi: 10.1016/j.pneurobio.2009.08.002. Epub 2009 Aug 21. Prog Neurobiol. 2009. PMID: 19699774 Review.
Cited by
-
Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves.Diabetes. 2016 Aug;65(8):2322-30. doi: 10.2337/db16-0284. Epub 2016 May 13. Diabetes. 2016. PMID: 27207540 Free PMC article.
-
Intra-axonal recording from large sensory myelinated axons: demonstration of impaired membrane conductances in early experimental diabetes.Diabetologia. 2003 Feb;46(2):213-21. doi: 10.1007/s00125-002-1026-z. Epub 2003 Feb 18. Diabetologia. 2003. PMID: 12627320
-
Diabetes mellitus differently affects electrical membrane properties of vagal afferent neurons of rats.Physiol Rep. 2023 Feb;11(4):e15605. doi: 10.14814/phy2.15605. Physiol Rep. 2023. PMID: 36807809 Free PMC article.
-
Abnormal muscle afferent function in a model of Taxol chemotherapy-induced painful neuropathy.J Neurophysiol. 2011 Jul;106(1):274-9. doi: 10.1152/jn.00141.2011. Epub 2011 May 11. J Neurophysiol. 2011. PMID: 21562188 Free PMC article.
-
Guidance of block needle insertion by electrical nerve stimulation: a pilot study of the resulting distribution of injected solution in dogs.Anesthesiology. 2008 Sep;109(3):473-8. doi: 10.1097/ALN.0b013e318182af0b. Anesthesiology. 2008. PMID: 18719445 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
