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Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.
The activity pattern of DRN GABAergic neurons, characterized by increased firing during retreats and decreased firing during the initiation of effortful behaviors in the tube test, illuminates their bidirectional regulatory role in social hierarchy.
This study conducted a comprehensive scRNA-seq of ovarian clear cell carcinoma (OCCC), identifying a malignant epithelial subcluster and 173 associated factors. Analysis highlighted crucial roles of STAT3, KLF5, and TRIM28, as a valuable resource for understanding OCCC.
The barnase-barstar pair is effective in Aedes aegypti as a basis for toxin-antidote gene drive systems, barnase is able to kill mosquitoes and cells and barstar rescues the effect in a ubiquitous or tissue-specific manner.
Activation of hypothalamic AgRP neurons promotes intake of the non-caloric sweetener saccharin in calorie-restricted mice, revealing their role in driving reward-driven consummatory behavior under energy deficit conditions.
RNA epitranscriptome analysis indicates the role of folate and folate-producing Lactobacillus plantarum in regulating neural mRNA m6A modification through carbon metabolism pathways in both Drosophila and mammals.
FRESH, a multi-lab collaboration, reveals how data quality, analysis pipelines, and researcher expertise influence reproducibility in fNIRS neuroimaging, highlighting key factors driving variability in hypothesis outcomes.
Brain network structure and local biology jointly shape ALS atrophy. Disease epicenters show transcriptomic enrichment for mitochondrial function, endothelial cells and pericytes. Individual variation in epicenters aligns with clinical symptoms.
Mechanistic insights into DNA polymerase IV–driven mutagenesis reveal its contribution to genome instability and the specific targeting of virulence-associated genes in Pseudomonas aeruginosa, underscoring its role in pathogen evolution and adaptation during infection.
Perception-action integration is related to connectivity strength in the alpha frequency band reflecting the maintenance of associations over time, and in the theta frequency band reflecting the organization of sequential information.
Detection of hydrogen sulfide by the neurons of the olfactory Grueneberg ganglion sheds light on a new kairomonal role for this toxic gas in predator-prey dynamics and danger communication
PLGA microspheres ensure controlled delivery of HEP14, which restores ovarian function in aged mice by inducing mitophagy and clearing reactive oxygen species via molecular rejuvenation.
SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thrombosis.
New cytoarchitectonic 3D maps reveal a detailed parcellation of the human premotor cortex into 3 dorsal and 4 ventral areas, advancing our understanding of motor and cognitive processes and related disorders.
The nucleus reuniens encodes associative value in both humans and rats. In rats, it also tracks defensive freezing states. The reuniens has a conserved role across species in modulating emotional memory processes and defensive states.
Single cell phospho-flow analysis of structure-activity relationships for the rocaglate natural product family identifies molecular features responsible for mTOR and DNA damage activity in leukemia cells.
The authors show that binding of 14-3-3ζ enhances cytosolic Tau solubility by promoting phosphorylated Tau removal from microtubules, while simultaneously inhibiting Tau aggregation both directly and indirectly via suppression of condensate formation.
