Developing durable catalysts for the acidic oxygen evolution reaction is crucial for proton exchange membrane water electrolyzers. Here, the authors report incorporating high-entropy atoms (Co, Ni, Cu, Mn, Sm) into RuO₂ via annealing, achieving stable operation at 1 A cm⁻² and 50 °C for 1500 h.

Researchers demonstrate arbitrary programming of light refraction through an engineered material, where the direction of the output wave can be set independently for different directions of the input wave.

Fracture resistance presents a challenge in mechanical metamaterials. Here, authors introduce dual-bond fracture metamaterials that enable full-field energy dissipation, making it tougher, more versatile, and better suited for advanced structural applications.

The applicability of the circularly polarized luminescence emitted from chiral substances is limited by their poor performance. Here, the authors describe the sequential amplification of circularly polarized luminescence of metal clusters to trigger enantioselective photopolymerization.

It is generally assumed that modulating magnetic properties via linear excitations of Raman-active phonons is forbidden in inversion symmetric magnets. Here, Luo, Ning, Ilyas, von Hoegen, and coauthors demonstrate a linear excitation of Raman-active lattice vibrations, via magnon-polaron excitation.

High-resolution sensitivity experiments show that tropical cyclones can induce long-term oceanic temperature perturbations, which affect the mean state and variability of the Kuroshio Current through geostrophic processes.

“Dissolved oxygen (DO) sustains river ecosystems, but the effects of hydrological extremes remain poorly understood. Here it is shown that sudden floods cause abrupt declines in DO, suggesting that increased future flooding may lead to the degradation of aquatic ecosystems.

Coastal migration under sea level rise is more likely in higher- than in lower-income contexts. Key determinants of migration include flood risk, response efficacy, self-efficacy, place attachment, and age. Important trade-offs exist between migration and in-situ flood adaptation.

Climate change is expected to impact microbes degrading organic matter in northern peatlands. Here, using a warming experiment, the authors show that communities remain stable after three years of warming, likely due to metabolic versatility and an ability to obtain electron acceptors from organic matter cleavage.

A cross-national survey in Latin America finds that emotional responses strongly predict climate risk perceptions. Unlike high-income countries, political ideology and socio-demographics have weak effects, suggesting opportunities for cross-party climate collaboration.

Embryo development is critical to seed development and grain yield in rice. Here, the authors show that mutation of brassinazole-resistance 4 (OsBZR4) cause embryoless phenotype with the possible involvement of auxin signaling and the penetration of the phenotype depending on genetic background and temperature.

The barrier function of skin epidermis requires polarized secretion of lamellar bodies towards the body surface. Here, Rudd et al. identify Flower (FWE) as a novel regulator of lamellar body trafficking and a determinant of epidermal barrier function.

Here they show that PIEZO1, a force-sensing ion channel, is important for trophoblast fusion during placental development. It triggers calcium entry that activates the TMEM16F lipid scramblase, allowing cells to merge and support fetal development.

Modular polyketide synthases (PKSs) are multi-domain enzymes responsible for the biosynthesis of polyketide antibiotics. Here, authors show the potential of ancestral sequence reconstruction to facilitate structural analysis of modular PKSs.

RNA-binding proteins (RBP) have been implicated in the regulation of inflammation, but mechanistic insights are still lacking. Here the authors profile RPBs to find ribosomal RNA processing 1 binding to thymidylate synthetase (TYMS) RNA to suppress TYMS expression and dampening macrophage one-carbon metabolism to suppress innate immunity.

Pressure overload in the heart, such as from aortic stenosis, triggers early molecular changes before visible damage occurs. Here, the authors show that combining proteomics, transcriptomics, and genetic data reveals key drivers of heart failure, highlighting potential targets for treatment.

Normothermic machine perfusion could prolong and/or improve preservation of kidneys in transplantation, but the technology has yet to reach clinical realization. Here, the authors show the hurdles, but also the solutions, for this technology to become a reality in transplantation and beyond.

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening condition different from self-limiting nature of Epstein-Barr virus-induced infectious mononucleosis (IM). Here the authors identify IDO1⁺ monocytes and L-kynurenine as biomarkers for HLH by comparing single cell sequencing data of HLH patients with IM and healthy volunteers as the controls.

Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

Chemotherapy-induced cardiotoxicity (CIC) is an adverse condition associated with several DNA damaging chemotherapeutics. Here, the authors discover that tumour ZNF281-mediated increase of purinergic signalling factors inosine and hypoxanthine promotes RBFOX1 degradation in cardiomyocytes, increasing the risk for developing CIC.

A cross-national survey in Latin America finds that emotional responses strongly predict climate risk perceptions. Unlike high-income countries, political ideology and socio-demographics have weak effects, suggesting opportunities for cross-party climate collaboration.

Reducing the size of the nanopesticide delivery system could improve pesticidal efficacy, but achieving unimolecular-sized nanosystems in a water-based process remains challenging. Here, the authors develop a water-based unimolecular platform that enhances cellular uptake, insect-dermis and leaf-cuticle penetration of pesticide, leading to improved field control efficacy against multiple pests.

Cui et al. find that open trade policy is a key factor for achieving low-cost solar photovoltaic supply chains. This conclusion holds even for regions, like Europe, that seek to localize solar production capacity.

Decisions are often assumed to depend on expected outcomes alone, with more profitable actions being favored. Here, the authors show that outcome uncertainty also shapes choices, such that less-sampled actions are avoided, independently of their value.

Aging US dams face increasing overtopping risks due to changing hydrologic conditions. This study evaluates 33 dams using updated frequency analysis and identifies six dams with the greatest probability, posing risks to downstream populations.