Browse Articles

The Soai reaction occupies a singular role in organic chemistry and chemical kinetics due to its autocatalytic and self-amplification behavior, which has spurred intense mechanistic investigation and debate. Here, the authors use in situ high-resolution mass spectrometry and accompanying techniques to identify reaction intermediates and bring about more granular detail of the reaction.

Developing highly active and robust catalysts remains a challenge for the implementation of nitrate reduction. The authors introduce a screw dislocation-mediated 3D printing strategy to fabricate curvature-controlled electrodes with 3D lattice strain, enhancing nitrate reduction performance.

Mitochondria coordinate with lysosomes to maintain cellular homeostasis. Here the authors show that mitochondrial defects can downregulate lysosomal alpha mannosidase VI which in turn, further impairs mitochondrial status.

Using high-resolution crystal structures, the authors discover that flavin adenine dinucleotide (FAD) facilitates the initiation of HCV RNA synthesis by interacting with key amino acids M447 and Y448 in NS5B. They also observe an elongation complex with an FAD-capped primer/product strand, explaining how the product strand moves for efficient RNA synthesis.

The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to match specific samples and hardware, overcoming the limitations of pre-designed pulses.

Filamentous phages Pf4 and Pf6 are integrated into Pseudomonas aeruginosa. Here, the authors investigate the crosstalk between these two prophages and reveal its contribution to biofilm formation, maintenance of polylysogeny and pathogenicity.

This study presents an experimental system to conditionally immortalize murine megakaryocyte-erythroid progenitor cells, providing a versatile system for investigation of red blood cell and platelet biology in vitro and in vivo.

Proximity effects in molecule/metal heterostructures offer a promising route to control magnetic properties. Here, the authors report a light-controlled proximity effect at a Co/C₆₀ interface, where laser-induced excitons in C₆₀ alter interfacial interactions, leading to a 60% quenching of the ferromagnetic resonance frequency of Co.

Mass spectrometry facilitates the scalable identification of cancer-specific HLA-bound peptides; however, the clinical identification of targets remains challenging. Here, the authors present NeoDiscMS, an immunopeptidomics method that enhances the identification of neoantigens while maintaining maximal global coverage of the tumor immunopeptidome.

Silver nanoparticles are used in a wide range of applications but have potential toxicity issues. Here, the authors report on a gut bacterium which can protect nematodes from reproductive harm caused by silver nanoparticles via the production of protective metabolites showing a strategy for mitigating nanoparticle toxicity.

The combination of isotopic tracers with root phenotyping reveals specific patterns in photosynthate allocation. These patterns are reflected in rhizodeposition and result in spatially distinct microbiomes within the plant root system.

Hemodynamic management is essential in critical care, but optimal targets for heart rate and blood pressure remain unclear. Here, the authors show that a time-dependent Cox model can derive personalized, real-time targets associated with reduced mortality.

Efficient oxygen activation limits oxidative catalysis. Here, incorporating single-atom Zr into CeO₂-supported Pt catalysts creates Zr₁–O–Pt₁ structures, significantly enhancing catalytic performance via boosted surface and chemisorbed oxygen activation.

Poly(A)-Binding Protein Cytoplasmic 1 (PABPC1) is a crucial component of stress granules. Here, the authors show that PABPC1 undergoes SUMOylation in response to cellular stress, enhancing the stability of mitophagy-related gene transcripts to promote cancer cell survival.

Human papillomavirus (HPV) DNA testing is the preferred method for cervical cancer screening, but existing tests are inaccessible for resource-limited settings. Here, authors develop a low-cost, simple HPV DNA assay suitable for bedside testing and demonstrate strong performance in Mozambique.

This study presents an ultracompact eye camera using a novel low aspect-ratio metalens design. Achieving a 120° field of view, the system enables high-performance gaze tracking and iris recognition, ideal for future augmented reality glasses.

Multi-omics can be used to characterise tumour and immune cell populations. Here the authors use multi-omics to characterise CLL blood and tissue samples and use prediction models for CLL TCR specificity and implicate interactions between galectin-9 and TIM3 as involved in CLL immune escape and propose galectin-9 as a possible immunotherapy target.

Wang et al. demonstrated that the nuclear envelope and mitochondria localized OPENER protein complex plays a key role in the pre-60Sribosome processing in plants.

Epimutations mediated by RNA interference can confer antifungal drug resistance and affect virulence in fungi. Here, the authors show that these epigenetic modifications can be transmitted across generations following sexual reproduction in a pathogenic fungus.