Pulsed Field Ablation Hub

A novel approach to cardiac ablation and the treatment of cardiac arrhythmias

Discover how pulsed field ablation (PFA) differs from thermal ablation techniques and explore the science of irreversible electroporation in this dedicated resource hub for advancing cardiac arrhythmia treatment.

Section Advisor:

Prof Lucas Boersma

This resource hub is supported by

The Fundamentals of PFA

Cell Death and Evolution of Lesions

Dr Atul Verma gives an overview of PFA, cell death and the sequence of events.

Anatomy of Pulse Waveforms

Dr Atul Verma explains the electroporation zones and how pulse parameters are optimised.

Catheter Design and Vectoring

Dr Atul Verma explains monopolar vectoring and bipolar vectoring.

Mitigation of PFA Specific Effects

Dr Atul Verma discusses hemolysis, coronary spasm and incidental heating.

Contact Versus Contact Force

Dr Atul Verma explains why contact matters with PFA.

Cell Specificity Versus Tissue-Specificity

Dr Atul Verma discusses whether PFA is really tissue specific or cell specific.

Durability Study With PulseSelect PFA System

Welcome

Khaldoun Tarakji gives a brief welcome, outlines the program and provides the educational goals for the session.

Lesion Durability and Workflow

Dr Devi Nair offers a comprehensive overview of lesion durability and workflow with the PulseSelect™ PFA System.

Standardized Workflow in a Multi-operator Center

Dr Gaurang Gandhi discusses the implementation of a standardized workflow in a multi-operator center.

Durability Study With PulseSelect PFA System

Panel Discussion and Q&A

The faculty answer audience questions, offer expert insights and participate in an interactive discussion.

PFA – Safety Considerations

Pulsed Field Ablation – Safety Considerations

In this video, Dr Atul Verma provides an insightful overview of the safety considerations associated with PFA.

The Fundamentals of Electroporation

Prof Damijan Miklavcic discusses how electroporation works, where it is used today and more.

The Fundamentals of Tissue Selectivity

Prof Damijan Miklavcic discusses tissue selectivity and what occurs on a cellular level.

PFA: Preclinical Evidence Review

Pulsed Field Ablation: Preclinical Evidence Review

Prof David Haines explores on the potential benefits of PFA, PFA ablation characteristics and more.

An Overview of PFA

An Overview of Pulsed Field Ablation

Dr Atul Verma presents a comprehensive overview of PFA, offering expert insights.

Insights From Our Experience With PulseSelect

Introduction and Insights From Our Experience With PulseSelect

Prof Lucas Boersma gives a brief welcome to the programme and introduces his experience with PulseSelect.

Not All PFA Is Created Equal

Key Safety Considerations and My Experience With PulseSelect

Dr Atul Verma presents the key safety considerations with PulseSelect and shares his own experience.

Not All PFA Is Created Equal

Discussion

Dr Atul Verma and Prof Lucas Boersma discuss their insights on PulseSelect PFA.

Implementing PulseSelect Into Daily Practice

Learnings and Early Results

Dr Stephen Tuohy presents his experience with PulseSelect and shares two detailed video case examples.

Implementing PulseSelect Into Daily Practice

Discussion

Prof Lucas Boersma, Dr Atul Verma and Dr Stephen Tuohy address key questions, providing expert responses and engaging in an interactive discussion.

Featured Video

Optimizing Ablation With the Zero-Exchange Workflow

Learn how FlexCath Cross™ transseptal solution enables the zero-exchange workflow with both PulseSelect™ pulsed field ablation system and Sphere-9™ mapping and ablation catheter supporting a more efficient and seamless clinician and patient experience.

Click here to register for the EP Insights Live Webinar Series

Key PFA Highlights From Congresses

The Next Era in Cardiac Ablation

EHRA 2025: The Next Era in Cardiac Ablation

At EHRA 2025, top experts gathered to discuss 'The Next Era in Cardiac Ablation: Elevating Efficiency, Safety and Long-term Outcomes'.

Latest in Pulsed Field Innovation

EHRA 2025: Latest in Pulsed Field Innovation

At EHRA 2025, top experts gathered to share their real-world insights on pulsed field ablation technologies during a high-impact session.

Cardiac Ablation With PFA

The Next Era of Cardiac Ablation With PFA

Step into a new era of cardiac ablation with the PulseSelect™ and Sphere-360™ single-shot catheters, and the Sphere-9™ catheter for wide area focal PF/RF.

*The Sphere-360 catheter is investigational and not for sale in any geography.

SPHERE Per-AF

Analysis From SPHERE Per-AF Randomized Trial

Impact of linear ablation in persistent AF on outcomes using a dual-energy, wide footprint ablation catheter.

Sphere-360 One-Year Outcomes

Heart Rhythm TV Update: Dr Vivek Reddy Discusses Medtronic’s Sphere-360 One-Year Outcomes

Dr Vivek Reddy shares one-year outcomes of Medtronic’s Sphere-360 at HRS 2025.

*The Sphere360 catheter is investigational and not for sale in any geography.

Sphere-9 for Linear Ablation

Dual-energy (RF/PF), focal Sphere-9™ catheter demonstrates efficacy for linear ablation in persistent AFib.

Sphere-360 Study Safety and Performance

One-year clinical trial data for the next-generation, investigational, Sphere-360™ single-shot PFA catheter show impressive safety, performance and efficiency results for paroxysmal Afib.

*The Sphere360 catheter is investigational and not for sale in any geography.

EHRA 2025

EHRA 25: Safety Results from the European Affera Ventricular Arrhythmia Ablation Registry

EHRA 2025 - Positive safety results of the Affera mapping and ablation system for the treatment of ventricular arrhythmias (VA) show a 6% rate of major complication.

Durability Late Breaker

Durability Late Breaker From APHRS 2024

In this video Dr Devi Nair presents the late breaking clinical trial results from APHRS 2024 'First Invasive Remapping to Assess Long-term Durability of Pulmonary Vein Isolation Using a Circular Pulsed Field Ablation Catheter'.

PulseSelect Real World Experience

HRS PulseSelect Real World Experience

Dr Arash Aryana talks through the clinical insights on using the PulseSelect PFA system for treating paroxysmal and persistent atrial fibrillation.

SPHERE Per-AF Results

HRS 2024: SPHERE Per-AF Study

Dr Elad Anter presents the SPHERE Per-AF IDE comparing Affera Sphere-9 with Thermocool STSF for treating Persistent AF.

A Streamlined Single Catheter Workflow

A Streamlined Single Catheter Workflow With Affera Sphere-9 Catheter

In this video from Rhythm Interventions Online 2024, Dr Erich Kiehl presents 'A Streamlined Single Catheter Workflow With Affera Sphere-9 Catheter'.

MANIFEST-PF

AFSymposium 24: MANIFEST-PF: Impact of LAPW Ablation During PFA for Persistent AF

AF Symposium 2024 – In this interview, investigator Dr Mohit K Turagam (Icahn School of Medicine at Mount Sinai, US) discusses the findings of a sub-study of the MANIFEST-PF registry.

Long-Term Effects of PFA

AFSymposium 24: Long-Term Effects of Pulsed Field Ablation on Coronary Arteries

Dr Yury Malyshev (Mount Sinai Hospital, US) joins us to discuss the findings from three studies focusing on the long-term effects of pulsed-field ablation (PFA) on coronary arteries.

Case Retrospective

RIO 2022 – Case Retrospective: Pulsed Field and Radiofrequency Ablation of Atrial Fibrillation Using Novel Focal Lattice Tip Catheter with Zero Fluoroscopy

Following the success of Rhythm Interventions Online 2022 (30 November – 2 December 2022), here Course Co-director and operator Dr Devi Nair reviews her Pulsed Field and Radiofrequency Ablation of Atrial Fibrillation Using Novel Focal Lattice Tip Catheter with Zero Fluoroscopy case performed live at the event.

The Five 'S' Strategy

RIO 2022 – Case Retrospective: Pulsed Field Ablation Using Sedation – The Five 'S' Strategy

Following the success of Rhythm Interventions Online 2022 (30 November – 2 December 2022), here Course Co-director and operator Prof Julian Chun reviews his Pulsed Field Ablation Using Sedation – The Five 'S' Strategy case performed live at the event.

The PULSED AF Trial

ACC 23: Pulsed Field Ablation in Persistent Atrial Fibrillation Patients: The PULSED AF Trial

Principal Investigator, Dr Atul Verma (McGill University Health Centre, CA) joins us on-site at ACC's 2023 Scientific Sessions to outline the findings of the PULSED-AF Trial (Medtronic Cardiac Rhythm and Heart Failure) (NCT04198701).

"Single Shot" PFA Catheter

EHRA 24: FIH Clinical Series of Conformable "Single Shot" PFA Catheter for PVI

EHRA 24 - We interview Dr Vivek Reddy (Icahn School of Medicine at Mount Sinai, US) on a first-in-human clinical trial of a novel conformable "single-shot" pulsed field ablation (PFA) catheter for pulmonary vein isolation (PVI).

The ADVENT RCT Results

The ADVENT RCT Results - FARAPULSE PFA vs. Thermal Standard-of-Care Ablation

Dr Vivek Reddy provides an overview of the ADVENT RCT results.

Novel Anatomical PFA

Raising the Bar in Pulsed Field Ablation Safety and Procedural Workflow With a Novel Anatomical PFA

Prof Gerhard Hindricks presents insights on elevating safety and improving procedural workflow in PFA.

Energy Source Selection

Energy Source Selection and Optimising Outcomes for AF Ablation

Dr Melanie Gunawardene presents Energy Source Selection and Optimising Outcomes for AF Ablation - The Case for PFA.

PFA Webinar Series

Welcome

Next Era of Cardiac Ablation: Welcome

JoEllyn Moore introduces the session, outlines the program and provides the educational goals.

Review of Affera Mapping

Next Era of Cardiac Ablation: Review of Affera Mapping and Ablation System and Sphere-9 Catheter

This talk, presented by Dr Jacob Koruth, provides a comprehensive review of the Affera™ Mapping and Ablation System along with the Sphere-9™ Catheter.

Real-World Experience

Next Era of Cardiac Ablation: Real-World Experience With Narration of Recorded Affera

Dr Douglas Gibson shares real-world experience using the Affera™ Mapping and Ablation System through the narration of a recorded clinical case.

Data Review

Next Era of Cardiac Ablation: Data Review, Learning Curve and Clinical Evidence

Dr Tyler Taigen reviews the clinical data and evidence supporting the use of the Affera™ Mapping and Ablation System.

Panel Discussion and Q&A

Next Era of Cardiac Ablation: Panel Discussion and Q&A

Faculty answer audience questions, offer expert insights and participate in an interactive discussion.

Welcome

Hemolysis With Different PFA Technologies: Welcome

Nishaki Mehta introduces the session, outlines the program and provides the educational goals.

Hemolysis Pathophysiology

Hemolysis With Different PFA Technologies: Hemolysis Pathophysiology and Clinical Implications

Dr Jay Raval presents a talk on the pathophysiology of hemolysis.

Hemolysis Incidence

Hemolysis With Different PFA Technologies: Hemolysis Incidence Across PFA Technologies

Dr Atul Verma discusses hemolysis with different PFA systems.

Real-World Experience

Hemolysis With Different PFA Technologies: Real-World Experience With PFA and Patient Selection

Dr Stavros Mountantonakis delivers a presentation on real-world experience with PFA and factors involved in selecting the right patients.

Panel Discussion and Q&A

Hemolysis With Different PFA Technologies: Panel Discussion and Q&A

The faculty answer audience questions, offer expert insights and participate in an interactive discussion.

Welcome

Durability Study With PulseSelect Pulsed Field Ablation (PFA) System and Real-World Experience: Welcome

Khaldoun Tarakji gives a brief welcome, outlines the program and provides the educational goals for the session.

Lesion Durability

Durability Study With PulseSelect Pulsed Field Ablation (PFA) System and Real-World Experience: Lesion Durability and Workflow

Dr Devi Nair offers a comprehensive overview of lesion durability and workflow with the PulseSelect™ PFA System.

Standardized Workflow

Durability Study With PulseSelect Pulsed Field Ablation (PFA) System and Real-World Experience: Standardized Workflow in a Multi-Operator Center

Dr Gaurang Gandhi discusses the implementation of a standardized workflow in a multi-operator center.

Panel Discussion and Q&A

Durability Study With PulseSelect Pulsed Field Ablation (PFA) System and Real-World Experience: Panel Discussion and Q&A

The faculty answer audience questions, offer expert insights and participate in an interactive discussion.

PFA Live Cases

Ischemic VT Ablation

Ischemic VT Ablation With Focal Lattice-Tip (Affera Sphere-9™; Medtronic)

Case Site: IKEM, Prague, Czech Republic

Case Operator: Josef Kautzner, MD

Large-Lattice One-Shot Catheter

PVI Using Large-Lattice One-Shot Catheter (Sphere360™; Medtronic)

Case Site: Na Homolce Hospital, Prague, Czech Republic

Case Operators: Vivek Reddy, MD, and Petr Neuzil, MD, PhD

PVI With Circular Array Catheter

PVI With Circular Array Catheter (PulseSelect™; Medtronic)

Case Site: Southcoast Health, Fall River, MA

Case Operator: Nitesh Sood, MD

AF Symposium 2025

Catheter Ablation for Persistent Atrial Fibrillation: Beyond PVI

Faculty deliver a series of presentations on the topic of 'Catheter Ablation for Persistent Atrial Fibrillation: Beyond PVI'.

AF Symposium 2025

Pulmonary Vein Isolation Using the SPHERE 360 Large Lattice Tip PFA Catheter

Prof Josef Kautzner presents a case at AF Symposium 2025.

AF Symposium 2025

Ablation of Persistent AF Using the PulseSelect Circular PFA Catheter

Dr Devi Nair presents a case at AF Symposium 2025.

AF Symposium 2025

Ablation of Paroxysmal AF Using the PulseSelect Circular PFA Catheter

A live case at AF Symposium 2025 from Lenox Hill Hospital, New York.

RIO 2024: Case & Discussion

Over-the-Wire PFA Loop Catheter and LAAO Concomitant Procedure

Chair: Bradley Knight (Chicago, US)

Case Operator: Usman Siddiqui (Florida Cardiology, Orlando, US)

Panel: Andrea Natale (Austin, US); Nitesh Sood (Boston, US)

RIO 2024: Live Case & Discussion

Enhanced Redo AF Ablation: High-Density Mapping With Dual RFC and PFA Integration

Chair: Devi Nair (Jonesboro, US)

Case Operator: Julian Chun and David Schaack (CCB Markus Krankenhaus, Frankfurt, DE)

Panel: Andreas Metzner (Hamburg, DE); Andrea Sarkozy (Brussels, BE)

RIO 2024: Case & Discussion

Easy and Safe PFA PVI With a Circular Over-the-Wire Array Catheter

Chair: Devi Nair (Arkansas, US)

Case Operator: Lucas Boersma (St Antonius Ziekenhuis, Nieuwegein, NL)

Panel: Andreas Metzner (Hamburg, DE); Suneet Mittal (New York, US)

PVI With the Sphere-9 Catheter

Live case: PVI With the Sphere-9 Catheter

In this PFA Live Case Summit you will see the Affera mapping and ablation system and lattice tip catheter used to treat a persistent AF patient.

PVI With PulseSelect PFA and 3D Mapping

Live Case: PVI With PulseSelect PFA and 3D Mapping

In this PFA Live Case Summit a circular array catheter will be used along with 3D mapping to conduct PV isolation.

VT Ablation With Sphere-9 Catheter

Live Case: VT Ablation With Sphere-9 Catheter

In this PFA Live Case Summit Prof Josef Kautzner will discuss the use of a focal lattice-tip to treat VT.

PVI With Sphere-360 Single Shot PFA

Live Case: PVI With Sphere-360 Single Shot PFA

In this PFA Live Case Summit Dr Vivek Reddy will discuss the use of a conformable lattice single shot PFA Catheter to treat a PAF patient.

RIO 2023 – Persistent AF

Persistent AF – High Density Mapping and Toggling PFA/RFC Ablation Based on Substrate

Prof Julian Chun and Dr Boris Schmidt present a live case from Rhythm Interventions Online 2023.

RIO 2023 – Future Options for AF Patients

Future Options for AF Patients – One-Stop Shop PVI + LAAC

Prof Julian Chun and Dr Boris Schmidt present a live case from Rhythm Interventions Online 2023.

Key PFA Trials

Initial real-world experiences

Initial real-world experiences of pulmonary vein isolation and ablation of non-pulmonary vein sites using a novel circular array pulsed field ablation catheter

Yogarajah J, Hutter J, Kahle P, et al. J Clin Med 2024;13:6961.

SPHERE Per-AF Pivotal Trial

Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial versus Thermocool STSF

Anter E, Mansour M, Nair DG, et al. Nat Med 2024;30:2303–10.

PULSED AF Pivotal Trial

Pulsed field ablation for the treatment of atrial fibrillation: PULSED AF pivotal trial

Verma A, Haines DE, Boersma LV, et al. Circulation 2023;147:1422–32.

ADMIRE Trial

Pulsed field ablation to treat paroxysmal atrial fibrillation: safety and effectiveness in the ADMIRE pivotal trial

Reddy VY, Calkins H, Mansour M, et al. Circulation 2024; epub ahead of press.

ADVENT Pivotal Trial

Pulsed field vs conventional thermal ablation for paroxysmal atrial fibrillation: recurrent atrial arrhythmia burden

Reddy VY, Mansour M, Calkins H, et al. J Am Coll Cardiol 2024;84:61–74.

PFA Registry and Survey Data

Catheter ablation for AF

Catheter ablation for atrial fibrillation: indications and future perspective

Natale A, Mohanty S, Sanders P, et al. Eur Heart J 2024;45:4383–98.

MANIFEST-17K Study

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Ekanem E, Neuzil P, Reichlin T, et al. Nat Med 2024;30:2020–9.

MANIFEST-PF Registry

Safety and effectiveness of pulsed field ablation to treat atrial fibrillation: one-year outcomes from the MANIFEST-PF registry

Turagam MK, Neuzil P, Schmidt B, et al. Circulation 2023;148:35–46.

Clinical Outcomes by Sex

Clinical outcomes by sex after pulsed field ablation of atrial fibrillation

Turagam MK, Neuzil P, Schmidt B, et al. JAMA Cardiol 2023;8:1142–51.

EU-PORIA Registry

EUropean real-world outcomes with Pulsed field ablatiOn in patients with symptomatic atRIAl fibrillation: lessons from the multi-centre EU-PORIA registry

Schmidt B, Bordignon S, Neven K, et al. Europace 2023;25:euad185.

MANIFEST-PF

Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF)

Ekanem E, Reddy VY, Schmidt B, et al. Europace 2022;24:1256–66.

Additional Publications

Operator Learning Curve

Operator learning curve with a novel dual-energy lattice-tip ablation system

Kiehl EL, Mountantonakis SE, Mansour MC, et al. Heart Rhythm 2025; epub ahead of press.

Complications associated with PFA

Complications associated with pulsed field ablation vs radiofrequency catheter ablation of atrial fibrillation

Cho MS, Lee SR, Black-Maier E, et al. Heart Rhythm 2024;epub ahead of press.

Methods and techniques

Methods and techniques to optimize energy delivery using the circular array pulsed field ablation catheter

Mountantonakis S, Beccarino N, Abrams M, et al. Heart Rhythm 2024;epub ahead of press.

Results of a Multicenter Analysis

Characterization and clinical significance of hemolysis after pulsed field ablation for atrial fibrillation: results of a multicenter analysis

Popa MA, Venier S, Menè R, et al. Circ Arrhythm Electrophysiol 2024:e012732.

Cardiac Ablation With Pulsed Electric Fields

Cardiac ablation with pulsed electric fields: principles and biophysics

Sugrue A, Maor E, Del-Carpio Munoz F, et al. Europace 2022;24:1213–22.

Secondary Analysis of the PULSED AF Trial

Prevalence, timing, and impact of early recurrence of atrial tachyarrhythmias after pulsed field ablation: A secondary analysis of the PULSED AF trial

Boersma LVA, Natale A, Haines D, et al. Heart Rhythm 2024; epub ahead of press.

PULSE-EU Trial

AF ablation using a novel "single-shot" map-and-ablate spherical array pulsed field ablation catheter: 1-Year outcomes of the first-in-human PULSE-EU trial

Turagam MK, Neuzil P, Petru J, et al. Heart Rhythm 2024;21:1218–26.

Highlights From 2023

The year in electrophysiology: selected highlights from 2023

Poorsattar SP, Kumar N, Vanneman M, et al. J Cardiothorac Vasc Anesth 2024;38:1641–9.

Large Footprint Focal Catheter

A large footprint focal catheter toggling between pulsed field and radiofrequency energy: first clinical experience for ventricular tachycardia ablation

Pannone L, Doundoulakis I, Cespón-Fernández M, et al. Europace 2024;26:euae193.

Catheter and Surgical Ablation for AF

2023 Cardiac Society of Australia and New Zealand Expert Position Statement on Catheter and Surgical Ablation for Atrial Fibrillation

Kistler PM, Sanders P, Amarena JV, et al. Heart Lung Circ 2024;33:828–81.

Patients With Recurrences

Pulsed field ablation for atrial fibrillation in real-life settings: Efficacy, safety, and lesion durability in patients with recurrences

Benali K, Vlachos K, Reddy VY, et al. Heart Rhythm 2024;21:962–4.

Pulsed-Field vs Cryoballoon vs Radiofrequency

Pulsed-field vs cryoballoon vs radiofrequency ablation: outcomes after pulmonary vein isolation in patients with persistent atrial fibrillation

Kueffer T, Stettler R, Maurhofer J, et al. Heart Rhythm 2024;21:1227–35.

PFA of the Right Superior Pulmonary Vein

Pulsed field ablation of the right superior pulmonary vein prevents vagal responses via anterior right ganglionated plexus modulation

Del Monte A, Della Rocca DG, Pannone L, et al. Heart Rhythm 2024;21:780–7.

Evolution and Future Perspective

State-of-the-art pulsed field ablation for cardiac arrhythmias: ongoing evolution and future perspective

Chun KJ, Miklavčič D, Vlachos K, et al. Europace 2024;26:euae134.

Results of a Multicenter, Real-world Experience

Pulsed field vs very high-power short-duration radiofrequency ablation for atrial fibrillation: Results of a multicenter, real-world experience

Dello Russo A, Compagnucci P, Anselmino M, et al. Heart Rhythm 2024; epub ahead of press.

Sequential Unipolar Biventricular PFA

Sequential unipolar biventricular pulsed field ablation for refractory intramural septal ventricular tachycardia

Cespón-Fernández M, Pannone L, Della Rocca D, et al. JACC Case Rep 2024;29:102356.

InspIRE

Predictors of success for pulmonary vein isolation with pulsed-field ablation using a variable-loop catheter with 3D mapping integration: complete 12-month outcomes from inspIRE

De Potter T, Grimaldi M, Duytschaever M, et al. Circ Arrhythm Electrophysiol 2024;17:e012667.

Repeat Catheter Ablation

Repeat catheter ablation for atrial fibrillation

Brahier MS, Friedman DJ, Bahnson TD, Piccini JP. Heart Rhythm 2024;21:471–83.

ADVENT Trial

Comparison of cerebral safety after atrial fibrillation using pulsed field and thermal ablation: Results of the neurological assessment subgroup in the ADVENT trial

Patel C, Gerstenfeld EP, Gupta SK, et al. Heart Rhythm 2024; epub ahead of press.

PFA vs Thermal Ablation

Cost, efficiency, and outcomes of pulsed field ablation vs thermal ablation for atrial fibrillation: a real-world study

Calvert P, Mills MT, Xydis P, et al. Heart Rhythm 2024; epub ahead of press.

Expert Consensus Statement

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation

Tzeis S, Gerstenfeld EP, Kalman J, et al. Heart Rhythm 2024; epub ahead of press.

Pulsed Field and Radiofrequency Ablation

A novel platform allowing for pulsed field and radiofrequency ablation: first commercial atrial fibrillation ablation procedures worldwide with and without general anesthesia

Metzner A, Rottner L, Moser F, et al. Heart Rhythm 2024;21:497–8.

Case Report

Case report: pulsed field ablation for epicardial right-sided accessory pathway

Haskova J, Peichl P, Borisincova E, Kautzner J. Front Cardiovasc Med 2024;11:1392264.

PFA Durability

Is seeing believing? Adding another tool to assess PFA durability

Mehta NK, Haines DE. Circ Arrhythm Electrophysiol 2024;17:e012773.

Endocardial PFA and the Oesophagus

Endocardial pulsed field ablation and the oesophagus: are atrio-oesophageal fistulas now history?

Nies M, Watanabe K, Kawamura I, Koruth JS. Arrhythm Electrophysiol Rev 2024;13:e02.

Learning Before Burning

Learning before burning: mapping with reversible pulsed field ablation

Ashur C, Tzou WS. Circ Arrhythm Electrophysiol 2024;17:e012430.

2023 ACC/AHA/ACCP/HRS Guideline

2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines

Writing Committee Members, Joglar JA, Chung MK, et al. J Am Coll Cardiol 2024;83:109–279.

Emerging Tools and Techniques

Emerging tools and techniques for catheter ablation of cardiac arrhythmias: a 2024 update

Aryana A, D'Avila A. J Innov Card Rhythm Manag 2024;15:5718–27.

Coronary Artery Spasm

Coronary artery spasm during pulsed field vs radiofrequency catheter ablation of the mitral isthmus

Zhang C, Neuzil P, Petru J, et al. JAMA Cardiol 2024;9:72–7.

2023 ACC/AHA/ACCP/HRS Guideline

Joglar JA, Chung MK, Armbruster AL, et al. Circulation 2024;149:e1–e156.

Paroxysmal Atrial Fibrillation Ablation

Pulsed electric field, cryoballoon, and radiofrequency for paroxysmal atrial fibrillation ablation: a propensity score-matched comparison

Della Rocca DG, Marcon L, Magnocavallo M, et al. Europace 2024;26:euae016.

Effects of Contact Force on Lesion Size

Effects of contact force on lesion size during pulsed field catheter ablation: histochemical characterization of ventricular lesion boundaries

Nakagawa H, Castellvi Q, Neal R, et al. Circ Arrhythm Electrophysiol 2024;17:e012026.

Guideline-Based Care for Atrial Fibrillation

Expert consensus on comprehensive early rhythm control in addition to guideline-based care for atrial fibrillation: a modified Delphi survey

Deering TF, Piccini JP, Graf M, et al. Am J Cardiol 2023;207:328–35.

Durability of PVI

Durability of pulmonary vein isolation for atrial fibrillation: a meta-analysis and systematic review

Serban T, Mannhart D, Abid QU, et al. Europace 2023;25:euad335.

Promise of PFA

The promise of pulsed field ablation and the challenges ahead

Iyengar SK, Iyengar S, Srivathsan K. Front Cardiovasc Med 2023;10:1235317.

Secondary Analysis of the PULSED AF Trial

Influence of monitoring and atrial arrhythmia burden on quality of life and health care utilization in patients undergoing pulsed field ablation: a secondary analysis of the PULSED AF trial

Verma A, Haines DE, Boersma LV, et al. Heart Rhythm 2023;20:1238–45.

Nonthermal Point-by-Point PVI

Nonthermal point-by-point pulmonary vein isolation using a novel pulsed field ablation system

Wenzel JP, Lemoine MD, Rottner L, et al. Circ Arrhythm Electrophysiol 2023;16:e012093.

Predicting Lesion Durability

Predicting lesion durability with PFA: one step closer

Koruth JS, Kawamura I. Circ Arrhythm Electrophysiol 2023;16:e012370.

Simultaneous PFA and Mechanical Closure

Simultaneous pulsed field ablation and mechanical closure of left atrial appendage using a novel device

Tang M, Wang X, Reddy VY. JACC Case Rep 2023;22:101963.

25 Years of Europace Journal

Progress in atrial fibrillation ablation during 25 years of Europace journal

Boersma L, Andrade JG, Betts T, et al. Europace 2023;25:euad244.

Efficacy, Safety, and Long-Term Follow-Up

Pulsed field versus cryoballoon pulmonary vein isolation for atrial fibrillation: efficacy, safety, and long-term follow-up in a 400-patient cohort

Urbanek L, Bordignon S, Schaack D, et al. Circ Arrhythm Electrophysiol 2023;16:389–98.

Silent Cerebral Lesions

Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review

Calvert P, Kollias G, Pürerfellner H, et al. Europace 2023;25:euad151.

Multicenter inspIRE Study

Paroxysmal atrial fibrillation ablation using a Novel variable-loop biphasic pulsed field ablation catheter integrated with a 3-dimensional mapping system: 1-year outcomes of the multicenter inspIRE study

Duytschaever M, De Potter T, Grimaldi M, et al. Circ Arrhythm Electrophysiol 2023;16:e011780.

Solving the Reach Problem

Solving the reach problem: a review of present and future approaches for addressing ventricular arrhythmias arising from deep substrate

Ravi V, Winterfield J, Liang J, et al. Arrhythm Electrophysiol Rev 2023;12:e04.

Efficacy and Safety of Novel PFA

Efficacy and safety of novel pulsed field ablation (PFA) technique for atrial fibrillation: A systematic review and meta-analysis

Shaheen N, Shaheen A, Ramadan A, Nashwan AJ. Health Sci Rep 2023;6:e1079.

MANIFEST-PF

Multi-national survey on the methods, efficacy, and safety on the post-approval clinical use of pulsed field ablation (MANIFEST-PF)

Ekanem E, Reddy VY, Schmidt B, et al. Europace 2022;24:1256–66.

Catheter Ablation of AF

Catheter ablation of atrial fibrillation: current status and near future

Yamane T. J Cardiol 2022;80:22–7.

PULSED AF Pilot Trial

First-in-human experience and acute procedural outcomes using a novel pulsed field ablation system: the PULSED AF pilot trial

Verma A, Boersma L, Haines DE, et al. Circ Arrhythm Electrophysiol 2022;15:e010168.

B-Ab06-02 PFA Trains

B-Ab06-02 pulsed field ablation trains reduce tissue impedance in patients undergoing pulmonary vein isolation

Shah KB, Mehta N, Kutinsky IB, et al. Heart Rhythm 2021;18:S10.

B-Po01-047 PFA and Heat Generation

B-Po01-047 pulsed field ablation and heat generation: electrode-tissue temperature analysis from the PULSED AF trial

Verma A, Boersma LVA, Haines DE, et al. Heart Rhythm 2021;18:S70.

Preclinical PFA Data

Hemolysis After PFA

Hemolysis after pulsed field ablation: the role of dose and contact in an acute porcine model

Mattison L, Verma A, Tarakji KG, Sigg DC. Circ Arrhythm Electrophysiol 2024:e013317.

Effect of Contact Force on PFA Lesions

Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue

Mattison L, Verma A, Tarakji KG, et al. J Cardiovasc Electrophysiol 2023;34:693–9.

Effects of Electrode-tissue Proximity

Effects of electrode-tissue proximity on cardiac lesion formation using pulsed field ablation

Howard B, Verma A, Tzou WS, et al. Circ Arrhythm Electrophysiol 2022;15:e011110.

Characterization of Phrenic Nerve Response

Characterization of phrenic nerve response to pulsed field ablation

Howard B, Haines DE, Verma A, et al. Circ Arrhythm Electrophysiol 2022;15:e010127.

PFA in a Porcine Model

Safety and chronic lesion characterization of pulsed field ablation in a Porcine model

Stewart MT, Haines DE, Miklavčič D, et al. J Cardiovasc Electrophysiol 2021;32:958–69.

Pulmonary Vein Stenosis and Collateral Damage

Reduction in pulmonary vein stenosis and collateral damage with pulsed field ablation compared with radiofrequency ablation in a canine model

Howard B, Haines DE, Verma A, et al. Circ Arrhythm Electrophysiol 2020;13:e008337.

Intracardiac PFA

Intracardiac pulsed field ablation: proof of feasibility in a chronic porcine model

Stewart MT, Haines DE, Verma A, et al. Heart Rhythm 2019;16:754–64.

Expandable Lattice Electrode Ablation Catheter

Expandable lattice electrode ablation catheter: a novel radiofrequency platform allowing high current at low density for rapid, titratable, and durable lesions

Barkagan M, Leshem E, Rottmann M, et al. Circ Arrhythm Electrophysiol 2019;12:e007090.

Novel Radiofrequency Catheter

Novel irrigated temperature-controlled lattice ablation catheter for ventricular ablation: a preclinical multimodality biophysical characterization

Shapira-Daniels A, Barkagan M, Yavin H, et al. Circ Arrhythm Electrophysiol 2019;12:e007661.

Feasibility, Safety, and Durability

Feasibility, safety, and durability of porcine atrial ablation using a lattice-tip temperature-controlled radiofrequency ablation catheter

Koruth JS, Kuroki K, Iwasawa J, at al. J Cardiovasc Electrophysiol 2020;31:1323–31.

Preclinical Assessment

Focal pulsed field ablation for pulmonary vein isolation and linear atrial lesions: a preclinical assessment of safety and durability

Koruth JS, Kuroki K, Kawamura I, at al. Circ Arrhythm Electrophysiol 2020;13:e008716.

PFA in Ventricular Myocardium

Pulsed-field ablation in ventricular myocardium using a focal catheter: the impact of application repetition on lesion dimensions

Yavin HD, Higuchi K, Sroubek J, et al. Circ Arrhythm Electrophysiol 2021;14:e010375.