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Review
. 2012 Oct 20;30(30):3675-86.
doi: 10.1200/JCO.2012.43.0116. Epub 2012 Sep 24.

Cancer- and cancer treatment-associated cognitive change: an update on the state of the science

Tim A Ahles  1 , James C Root, Elizabeth L Ryan
Affiliations
Review

Cancer- and cancer treatment-associated cognitive change: an update on the state of the science

Tim A Ahles et al. J Clin Oncol. .

Abstract

Cognitive changes associated with cancer and cancer treatments have become an increasing concern. Using breast cancer as the prototype, we reviewed the research from neuropsychological, imaging, genetic, and animal studies that have examined pre- and post-treatment cognitive change. An impressive body of research supports the contention that a subgroup of patients is vulnerable to post-treatment cognitive problems. We also propose that models of aging may be a useful conceptual framework for guiding research in this area and suggest that a useful perspective may be viewing cognitive change in patients with cancer within the context of factors that influence the trajectory of normal aging.

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Conflict of interest statement

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

Figures

Fig 1.
Fig 1.
Pre- to post-treatment change in processing speed by treatment, age group, and level of cognitive reserve, assessed by the Wide Range Achievement Test (WRAT) –Reading. (A) WRAT below median; (B) WRAT above median.
Fig 2.
Fig 2.
Trajectories of cognitive change.
See this image and copyright information in PMC

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References

    1. Ahles TA, Correa DD. Neuropsychological impact of cancer and cancer treatments. In: Holland JC, editor. Psycho-Oncology. ed 2. New York, NY: Oxford University Press; 2010. pp. 251–257.
    1. Anderson FS, Kunin-Batson AS. Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function. Pediatr Blood Cancer. 2009;52:159–164. - PubMed
    1. Oxman TE, Silberfarb PM. Serial cognitive testing in cancer patients receiving chemotherapy. Am J Psychiatry. 1980;137:1263–1265. - PubMed
    1. Tannock IF, Ahles TA, Ganz PA, et al. Cognitive impairment associated with chemotherapy for cancer: Report of a workshop. J Clin Oncol. 2004;22:2233–2239. - PubMed
    1. Vardy J, Wefel JS, Ahles TA, et al. Cancer and cancer-therapy related cognitive dysfunction: An international perspective from the Venice Cognitive Workshop. Ann Oncol. 2008;19:623–629. - PubMed

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