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. 2011 May 10;76(19):1674-6.
doi: 10.1212/WNL.0b013e318219faf6. Epub 2011 Mar 30.

Lafora bodies in skeletal muscle are fiber type specific

J Turnbull  1 , J-M Girard, N Pencea, X Zhao, T E Graham, P Wang, C A Ackerley, B A Minassian
Affiliations

Lafora bodies in skeletal muscle are fiber type specific

J Turnbull et al. Neurology. .
No abstract available

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Figures

Figure
Figure. Lafora bodies (LB) are predominantly in type IIB myofibers
(A) LB are not in all myofibers; stain, PAS-D; LB are the purple contents within fibers. (B) LB are in type IIB fibers; type IIB antibody BF-F3 and PAS-D costaining; LB are the purple contents of antibody-positive (brown) cells. (C, D) LB are not in type I fibers; (C) mATPase histochemical stain at pH 4.3; darkly stained cells are type I fibers. (D) PAS-D-stained serial section; black dots are the type I cells in C. (E) The vast majority of type IIA fibers (brown) do not contain LB; type IIA antibody SC-71. (F) The vast majority of type IID fibers (darker color) do not contain LB; type IID antibody 6H1. (G, H) Five LB-containing fibers shown, 4 type IIB (asterisks) and 1 type IID (arrowheads); (G) mATPase histochemical stain at pH 4.6; the darkest fibers are type I, second-darkest IID, and the large pale fibers IIB. (H) PAS-D-stained serial section to G. With the exception of (A), all staining was on frozen sections. Techniques were standard.e1 (Reference e1 is available on the Neurology® Web site at www.neurology.org.) All bars equal 100 μm.
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